Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats.
Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats.
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DOI：
10.3390/antiox10111754
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发表时间：
2021-11-03
期刊：
影响因子：
--
通讯作者：
Kitada M
中科院分区：
文献类型：
--
作者：
Monno I;Ogura Y;Xu J;Koya D;Kitada M
改善生活方式，包括通过锻炼，已被认为是抑制糖尿病肾病(DKD)的一种重要治疗模式。然而，运动在抑制DKD中发挥有益作用的详细分子机制尚未完全阐明。在本研究中，我们观察了8周(13m/min，30min/d，5天/周)的跑台运动训练(TET)对36周龄2型糖尿病肥胖雄性大鼠(Wistar肥胖大鼠：WFRs)肾脏损伤的影响。Tet显著抑制WFR大鼠的蛋白尿和尿肝型脂肪酸结合蛋白(L-FABP)水平、肾小管间质纤维化、炎症和氧化应激。此外，Tet还可减轻肾皮质细胞过度凋亡和恢复自噬，抑制近端肾小管细胞线粒体形态异常的发展，同时还可恢复AMPK活性，抑制雷帕霉素复合体1的机械靶点(MTORC1)。结论：粉防己碱可改善2型糖尿病肥胖大鼠糖尿病所致的肾损伤。
Lifestyle improvement, including through exercise, has been recognized as an important mode of therapy for the suppression of diabetic kidney disease (DKD). However, the detailed molecular mechanisms by which exercise exerts beneficial effects in the suppression of DKD have not yet been fully elucidated. In this study, we investigate the effects of treadmill exercise training (TET) for 8 weeks (13 m/min, 30 min/day, 5 days/week) on kidney injuries of type 2 diabetic male rats with obesity (Wistar fatty (fa/fa) rats: WFRs) at 36 weeks of age. TET significantly suppressed the levels of albuminuria and urinary liver-type fatty-acid-binding protein (L-FABP), tubulointerstitial fibrosis, inflammation, and oxidative stress in the kidneys of WFRs. In addition, TET mitigated excessive apoptosis and restored autophagy in the renal cortex, as well as suppressed the development of morphological abnormalities in the mitochondria of proximal tubular cells, which were also accompanied by the restoration of AMP-activated kinase (AMPK) activity and suppression of the mechanistic target of rapamycin complex 1 (mTORC1). In conclusion, TET ameliorates diabetes-induced kidney injury in type 2 diabetic fatty rats.
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影响因子：
3.7
作者：
Ito D;Cao P;Kakihana T;Sato E;Suda C;Muroya Y;Ogawa Y;Hu G;Ishii T;Ito O;Kohzuki M;Kiyomoto H
通讯作者：
Kiyomoto H
影响因子：
11.4
作者：
Heiss, Elke H.;Schachner, Daniel;Zimmermann, Kristin;Dirsch, Verena M.
通讯作者：
Dirsch, Verena M.
影响因子：
5.6
作者：
Juszczak F;Vlassembrouck M;Botton O;Zwakhals T;Decarnoncle M;Tassin A;Caron N;Declèves AE
通讯作者：
Declèves AE
影响因子：
3.2
作者：
Kitada M;Zhang Z;Mima A;King GL
通讯作者：
King GL
DOI：
10.2215/cjn.08410814
发表时间：
2015-07-01
影响因子：
9.8
作者：
Beddhu, Srinivasan;Wei, Guo;Greene, Tom
通讯作者：
Greene, Tom