Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation.
Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation.
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DOI：
10.1186/1742-2094-9-77
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发表时间：
2012-04-25
影响因子：
9.3
通讯作者：
Wilson EH
中科院分区：
文献类型：
--
作者：
Noor S;Wilson EH
几十年来，趋化因子及其受体因其在炎症和免疫过程中控制白细胞功能的多重作用而受到极大关注。趋化因子传递显著通用但环境特异性信号的能力将其鉴定为响应于多种病原性或非感染性损伤而产生的免疫应答的强大调节剂。最近的一些研究推测，C-C趋化因子受体7型（CCR 7），在炎症和免疫监视过程中，在各种组织区室中的免疫细胞运输中发挥重要作用。使用计算建模和基于微流体的方法，最近的研究已经探索了白细胞迁移行为，在与其他共存的趋化因子领域存在的复杂趋化因子环境中响应于CCR 7配体。在这篇综述中，我们总结了目前的理解的影响，可溶性与固定化配体和下游信号通路的CCR 7控制白细胞的运动性，方向性和速度。这篇综述还整合了目前的知识，CCR 7在协调免疫反应之间的次级淋巴器官和外周组织微环境中的主要或次要抗原遇到的作用。CCR 7似乎影响中枢神经系统（CNS）炎症反应期间的不同免疫事件，包括免疫细胞进入和迁移，以及神经胶质细胞相互作用。临床和病理结果可能会有所不同，这取决于它在发炎的CNS微环境中的作用。了解这些机制对治疗发展有直接影响，有利于更多的保护性和有效的免疫反应。
For decades, chemokines and their receptors have received a great deal of attention for their multiple roles in controlling leukocyte functions during inflammation and immunity. The ability of chemokines to convey remarkably versatile but context-specific signals identifies them as powerful modulators of immune responses generated in response to diverse pathogenic or non-infectious insults. A number of recent studies have speculated that the C-C chemokine receptor type 7 (CCR7), plays important roles in immune-cell trafficking in various tissue compartments during inflammation and in immune surveillance. Using computational modeling and microfluidics-based approaches, recent studies have explored leukocyte migration behavior in response to CCR7 ligands in a complex chemokine environment existing with other coexisting chemokine fields. In this review, we summarize the current understanding of the effects of soluble versus immobilized ligands and of the downstream signaling pathways of CCR7 that control leukocyte motility, directionality, and speed. This review also integrates the current knowledge about the role of CCR7 in coordinating immune responses between secondary lymphoid organs and peripheral tissue microenvironments during primary or secondary antigen encounters. CCR7 seems to influence distinct immunological events during inflammatory responses in the central nervous system (CNS) including immune-cell entry and migration, and neuroglial interactions. The clinical and pathological outcome may vary depending on its contribution in the inflamed CNS microenvironment. Understanding these mechanisms has direct implications for therapeutic developments favoring more protective and efficient immune responses.
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影响因子：
20.3
作者：
Davalos-Misslitz, Ana C. M.;Worbs, Tim;Foerster, Reinhold
通讯作者：
Foerster, Reinhold
影响因子：
6.2
作者：
Biber, K;Sauter, A;Boddeke, HWGM
通讯作者：
Boddeke, HWGM
影响因子：
4.4
作者：
Eo, SK;Kumaraguru, U;Rouse, BT
通讯作者：
Rouse, BT
影响因子：
3.6
作者：
Ebert, LA;Schaerli, P;Moser, B
通讯作者：
Moser, B
影响因子：
4.4
作者：
Dijkstra, IM;Hulshof, S;Biber, K
通讯作者：
Biber, K