FLOW RESTRICTION OF ONE CAROTID-ARTERY IN JUVENILE RATS INHIBITS GROWTH OF ARTERIAL DIAMETER
FLOW RESTRICTION OF ONE CAROTID-ARTERY IN JUVENILE RATS INHIBITS GROWTH OF ARTERIAL DIAMETER
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DOI：
10.1152/ajpheart.1985.248.4.h540
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发表时间：
1985-01-01
影响因子：
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通讯作者：
HARTLEY, CJ
中科院分区：
文献类型：
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作者：
GUYTON, JR;HARTLEY, CJ
长期以来，人们一直假设血流量是动脉直径增长的主要决定因素。为了验证这一假设，13只大鼠（45-65 g）在一条颈动脉上放置了一个限制流动的银夹，在对侧动脉上放置了一个完全不闭塞的银夹。6-12周后，在夹片附近测量血管直径和脉冲多普勒速度波形，其中一侧与另一侧的流量不同，但可以假设平均压力大致相等。在这些测定之前，大鼠被麻醉，然后在正常动脉压下立即灌注固定。紧夹侧的流量平均减少35%。血流受限动脉一致显示直径增长减少，平均为对照组直径的-10.2% （P = 0.001）。在流动受限侧和控制侧，膜层介质的厚度相似。两侧管腔周长比与平均血流速度无关，但与峰值血流速度相关（r = 0.62），与流速脉动指数相关（r = 0.80）。这些结果证实了血流量和动脉直径之间的关系，并提出了血流脉动的可能性。
Blood flow has long been hypothesized to be a primary determinant of arterial diameter growth. To verify this hypothesis, a flow-restricting silver clip was placed on one carotid artery and a completely nonocclusive clip on the contralateral artery in 13 rats (45-65 g). After 6-12 wk, measurements of vessel diameters and pulsed Doppler velocity waveforms were obtained proximal to the clips, where flows differed from one side to the other, but mean pressures could be assumed approximately equal. Rats were anesthetized prior to these determinations and were fixed by perfusion at normal arterial pressure immediately thereafter. Flow reduction on the tightly clipped side averaged 35%. Flow-restricted arteries consistently showed reduction of diameter growth, averaging -10.2% of control diameters (P = 0.001). Thicknesses of the tunica media were similar on the flow-restricted and control sides. Side-to-side lumen circumference ratios were not correlated with mean blood flow velocities but were correlated with peak velocity (r = 0.62) and with an index of velocity pulsatility (r = 0.80). These results confirm a relationship between blood flow and arterial diameter and raise the possibility of a role for flow pulsatility.