Characterizations of the TiO2-x films synthesized by e-beam evaporation for endovascular applications
Characterizations of the TiO2-x films synthesized by e-beam evaporation for endovascular applications
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DOI：
10.1088/1748-6041/4/1/015013
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发表时间：
2009-02-01
影响因子：
4
通讯作者：
Chung, Sung-Min
中科院分区：
文献类型：
--
作者：
Lin, Zeng;Lee, In-Seop;Chung, Sung-Min
采用电子束蒸发技术，在不同氧气流量下，在工业纯钛(Cp-Ti)上沉积了不同化学状态的氧化钛薄膜，以考察其在血管内支架中应用的可能性。用FE-SEM、XPS和X射线衍射仪分析了所得氧化钛薄膜的表面形貌、化学成分和晶体结构。随着沉积参数的不同，所得到的氧化钛薄膜呈现出不同的锐钛矿相、二氧化钛和二氧化钛的混合物。通过在CP钛板上形成氧化钛薄膜，降低了接触角，提高了猪主动脉平滑肌细胞的活性。沉积后的热处理也被发现是实现良好的生物相容性的一个重要因素。当通过观察富含血小板的血浆中血小板的粘附性来考察血液相容性时，在二氧化钛薄膜上观察到的血小板粘附性较少。这些结果表明，电子束蒸发法制备的氧化钛薄膜可用于冠状动脉支架。
Different chemical states of titanium oxide films were deposited on commercially pure Ti (CP Ti) by electron-beam evaporation at different oxygen flow rates to examine a possibility of their applications to endovascular stents. The surface morphology, chemical composition and crystal structure of the obtained titanium oxide films were analyzed by FE-SEM, XPS and XRD, respectively. As a function of the deposition parameters employed, the obtained titanium oxide films demonstrated different mixtures of anatase phase, Ti2O3 and TiO. By the formation of titanium oxide film on the CP Ti plate, the contact angle was decreased and the cellular activity of porcine aortic smooth muscle cells was increased. Post-deposition annealing was also found to be an important factor to achieve advantageous biocompatibility. When haemocompatibility was investigated by observing adhesion of blood platelets from platelet-rich plasma, less platelet adhesion was observed on titanium oxide films. These results indicated that titanium oxide film synthesized by e-beam evaporation could be applicable to coronary stents.