BREAST-FEEDING AND THE RISK OF SEVERE CHOLERA IN RURAL BANGLADESHI CHILDREN
BREAST-FEEDING AND THE RISK OF SEVERE CHOLERA IN RURAL BANGLADESHI CHILDREN
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DOI：
10.1093/oxfordjournals.aje.a115515
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发表时间：
1990-03-01
影响因子：
5
通讯作者：
HOLMGREN, J
中科院分区：
文献类型：
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作者：
CLEMENS, JD;SACK, DA;HOLMGREN, J
在一项针对36个月以下孟加拉国农村儿童的病例对照研究中，研究了母乳喂养与严重霍乱风险之间的关系，这些儿童是在1985-1986年对灭活口服霍乱疫苗进行现场试验期间进行研究的。共有116例因严重霍乱接受治疗的病例与464例年龄匹配的社区对照进行了比较。总体而言，母乳喂养与严重霍乱相关的比值比（0.30，p < 0.0001）反映了母乳喂养儿童中严重霍乱风险降低70%。估计的风险降低随着年龄的增长而下降，但在30个月以下的儿童中非常明显。尽管母乳喂养与严重霍乱风险降低之间的相关性在试验期间接受霍乱疫苗的母亲的孩子中并不比母亲接受安慰剂的孩子中显着更大，但母亲接种疫苗本身与严重霍乱风险降低之间存在显着相关性未接种疫苗的儿童（优势比= 0.53，p = 0.05）。这些结果表明，母乳喂养与严重霍乱风险的大幅降低有关，并提高了母亲接种疫苗可能为流行环境中的幼儿提供保护的可能性。
The association between breast feeding and the risk of severe cholera was examined in a case-control study of rural Bangladeshi children under 36 months of age who were studied in 1985-1986 during a field trial of killed oral cholera vaccines. A total of 116 cases who were treated for severe cholera were compared with 464 age-matched community controls without severe cholera. Overall, the odds ratio relating breast feeding to severe cholera (0.30, p < 0.0001) reflected a 70% reduction in the risk of severe cholera among breast-fed children. The estimated reduction of risk declined with age, but was clearly evident in children up to 30 months of age. Although the association between breast feeding and a reduced risk of severe cholera was not significantly greater in children of mothers who had received cholera vaccine than in children whose mothers had received placebo during the trial, maternal vaccination per se was suggestively associated with a reduced risk of severe cholera in their nonvaccinated children (odds ratio = 0.53, p = 0.05). These results indicate that breast feeding was associated with a substantial reduction of the risk of severe cholera and raise the possibility that vaccination of mothers may provide protection to their young children in endemic settings.