Chronic neutropenia of childhood: frequent association with parvovirus infection and correlations with bone marrow culture studies
Chronic neutropenia of childhood: frequent association with parvovirus infection and correlations with bone marrow culture studies
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儿童慢性中性粒细胞减少症：与细小病毒感染频繁相关以及与骨髓培养研究的相关性
DOI：
10.1111/j.1365-2141.1993.tb08645.x
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发表时间：
1993
影响因子：
6.5
通讯作者：
D. Mahoney
中科院分区：
文献类型：
--
作者：
K. McClain;Z. Estrov;Hong Chen;D. Mahoney
摘要持续时间超过3个月的中性粒细胞减少症儿童通常有免疫介导的成熟中性粒细胞破坏和骨髓中髓样前体细胞变异异常的证据。这些患者通常具有持续数月的抗中性粒细胞抗体。为了进一步研究此类患者中性粒细胞减少症的病因，评价了骨髓细胞中常见病毒的存在。19例患者中有15例通过用细小病毒特异性引物对骨髓DNA进行PCR扩增检测有细小病毒感染的证据。在这15例患者中，6例也有细小病毒感染的血清学证据。在12例细小病毒感染患者中的9例中鉴定出抗中性粒细胞抗体。对6名患者进行的骨髓培养研究显示，患者血浆对骨髓和红细胞有不同程度的抑制作用。这些研究表明，细小病毒可能是儿童免疫介导的中性粒细胞减少症的常见原因。
Summary. Children with neutropenia of more than 3 months duration often have evidence of immune‐mediated destruction of mature neutrophils and variable abnormalities of myeloid precursors in their bone marrow. These patients often have anti‐neutrophil antibodies which persist for several months. To further investigate the aetiology of neutropenia in such patients, bone marrow cells were evaluated for the presence of common viruses. Fifteen of 19 patients tested had evidence for parvovirus infection by PCR amplification of bone marrow DNA with parvovirus specific primers. Of these 15, six also had serologic evidence of parvovirus infection. Anti‐neutrophil antibodies were identified in nine of 12 patients with parvovirus infection. Bone marrow culture studies done on six patients revealed varying degrees of myeloid and erythroid inhibition by patient plasma. These studies indicate that parvovirus may be a common cause of immune‐mediated neutropenia in children.
婴儿期原发性自身免疫性中性粒细胞减少症的自然史。
影响因子：
8
作者：
Conway,LT;Clay,ME;Kline,WE;Ramsay,NK;Krivit,W;McCullough,J
通讯作者：
McCullough,J