Structure-Function Relationship in Glaucoma Using Spectral-Domain Optical Coherence Tomography
Structure-Function Relationship in Glaucoma Using Spectral-Domain Optical Coherence Tomography
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DOI：
10.1001/archophthalmol.2011.145
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发表时间：
2011-07-01
影响因子：
--
通讯作者：
Medeiros, Felipe A.
中科院分区：
文献类型：
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作者：
Rao, Harsha L.;Zangwill, Linda M.;Medeiros, Felipe A.
目的：使用谱域光学相干断层扫描 (SDOCT) 衍生的结构测量确定青光眼的结构-功能关系，并使用线性模型评估这种关系。方法：在一项横断面研究中，确定了 DIGS（青光眼诊断创新研究）和 ADAGES（非洲人后裔和青光眼评估研究）的所有参与者的结构-功能关系，这些参与者接受了标准自动视野检查 (SAP) 和SDOCT 彼此间隔 6 个月内。关系强度报告为决定系数 (R(2))。还使用先前描述的线性模型评估了这种关系。 结果：分析了 47 名对照受试者的 80 只眼睛、130 名疑似青光眼患者的 199 只眼睛和 146 名青光眼患者的 213 只眼睛的 579 次 SAP 和 SDOCT 检查结果。 SAP 总偏差与 SDOCT 变量之间关联的 R(2) 范围从鼻缘区域的 0.01 (P=.02) 到黄斑处下视网膜内部厚度的 0.30 (P=.001)。线性模型很好地拟合了数据。结论：使用 SDOCT 发现弓形区域的视网膜神经纤维层测量和黄斑测量的内部视网膜厚度具有最强的结构-功能关联。线性模型可用于研究青光眼的结构-功能关系。
Objectives: To determine the structure-function relationship in glaucoma using spectral-domain optical coherence tomography (SDOCT)-derived structural measurements and to evaluate this relationship using a linear model.Methods: In a cross-sectional study, structure-function relationships were determined for all the participants in the DIGS (Diagnostic Innovations in Glaucoma Study) and the ADAGES (African Descent and Glaucoma Evaluation Study) who had undergone standard automated perimetry (SAP) and SDOCT within 6 months of each other. Strength of relationship was reported as coefficient of determination (R(2)). The relationship was also evaluated using a previously described linear model.Results: The results of 579 SAP and SDOCT examinations from 80 eyes of 47 control subjects, 199 eyes of 130 patients with suspected glaucoma, and 213 eyes of 146 patients with glaucoma were analyzed. The R(2) for the association between SAP total deviation and SDOCT variables ranged from 0.01 (P=.02) for the nasal rim area to 0.30 (P=.001) for inferior inner retinal thickness at the macula. The linear model fitted the data well.Conclusions: The strongest structure-function associations using SDOCT were found for retinal nerve fiber layer measurements at arcuate areas and inner retinal thickness at the macula measurements. The linear model is useful in studying the structure-function relationship in glaucoma.