COMPARISON OF EFFECTS OF A SYNTHETIC POLYRIBONUCLEOTIDE WITH EFFECTS OF ENDOTOXIN ON SELECTED HOST RESPONSES
COMPARISON OF EFFECTS OF A SYNTHETIC POLYRIBONUCLEOTIDE WITH EFFECTS OF ENDOTOXIN ON SELECTED HOST RESPONSES
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DOI：
10.1128/iai.3.3.444-448.1971
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发表时间：
1971-01-01
影响因子：
3.1
通讯作者：
ACTOR, P
中科院分区：
文献类型：
--
作者：
BERRY, LJ;SMYTHE, DS;ACTOR, P
注射小剂量（1 ~ 50 μg）合成的聚核糖肌苷酸与聚核糖胞苷酸复合物（poly I：poly C）可抑制醋酸可的松对色氨酸加氧酶的诱导作用，诱导酪氨酸氨基转移酶，并加速肝糖原储备的损失。它也导致了第一个抑制，然后是网状内皮系统的激活，判断从血液中的碳清除率。所有这些反应都是由相当剂量的内毒素引起的。用poly I：poly C预处理小鼠没有或仅略微增加其对几种细菌病原体感染的非特异性抵抗力，并且它未能导致对内毒素的耐受性的发展，已知内毒素在类似条件下产生的作用。
An injection of a small dose (1 to 50 μg) of synthetic polyriboinosinic acid complexed with polyribocytidylic acid (poly I:poly C) inhibited the induction of tryptophan oxygenase by cortisone acetate; it induced tyrosine amino transferase, and it accelerated the loss of liver glycogen reserves. It also resulted in first a suppression followed by an activation of the reticuloendothelial system as judged by the rates of carbon clearance from blood. All of these responses are elicited by comparable doses of endotoxin. Pretreatment of mice with poly I:poly C did not, or only marginally, increased their nonspecific resistance to infection with several bacterial pathogens, and it failed to result in the development of tolerance to endotoxin, effects known to be produced by endotoxin when given under similar conditions.