Increased Fatigability of the Gastrocnemius Medialis Muscle in Individuals with Intermittent Claudication
Increased Fatigability of the Gastrocnemius Medialis Muscle in Individuals with Intermittent Claudication
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DOI：
10.1016/j.ejvs.2012.04.024
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发表时间：
2012-08-01
影响因子：
5.7
通讯作者：
Pisot, R.
中科院分区：
文献类型：
--
作者：
Gasparini, M.;Sabovic, M.;Pisot, R.
背景：我们试图确定健康对照者和外周动脉疾病（PAD）和间歇性下肢跛行患者腓肠肌内侧肌（GM）收缩力的可能差异。方法：对17例PAD患者和17例健康对照者进行GM肌张力图检查。用单个或多个电脉冲触发肌肉收缩，并测量收缩的时间和幅度。结果：单脉冲刺激后，PAD患者GM肌收缩时间明显短于对照组（P < 0.001）。在1分钟的重复电刺激期间，对照组的GM肌肉的收缩速度通常在整个刺激期间持续增加，而PAD患者在30秒后观察到收缩速度明显下降。肌肉疲劳的发作与检查腿的踝肱指数（ABI）无关。将ABIs较高和较低的PAD患者的腿部进行比较，单脉冲刺激后的收缩时间和幅度无显著差异。结论：间歇性跛行患者的GM肌比健康对照者收缩更快，疲劳更早。因为收缩时间，用张力肌图测量，反映了个体的肌纤维组成，我们的研究结果可能反映了PAD患者GM肌肉从I型纤维到II型纤维的转变。我们的数据支持小腿肌病存在于跛行倾向患者的观点，并在一定程度上决定了PAD的临床表现。(C) 2012年欧洲血管外科学会。Elsevier Ltd.出版。版权所有。
Background: We attempted to identify possible differences in the contractility of the gastrocnemius medialis (GM) muscle between healthy controls and individuals with peripheral arterial disease (PAD) and intermittent lower-limb claudication.Methods: The GM muscles of 17 PAD patients and 17 healthy controls were examined with tensiomyography. Single or multiple electrical impulses were used to trigger muscle contractions, and the time and amplitude of Contractions were measured.Results: After single-impulse stimulation, the GM muscles of PAD patients showed significantly shorter contraction times (P < 0.001) than the GM muscles of controls. During 1 min of repetitive electrical stimulation, the contraction velocity of the controls' GM muscles typically showed a sustained increase throughout the stimulation period, whereas in PAD patients, a significant decrease in contraction velocity was observed after 30 s. The onset of muscle fatigue was unrelated to the ankle brachial index (ABI) of the examined leg. When the legs of PAD patients with higher and lower ABIs were compared to each other, no significant differences were found regarding the time and amplitude of contraction after single-impulse stimulation.Conclusions: The GM muscles of individuals with intermittent claudication contract more quickly and fatigue earlier than the GM muscles of healthy controls. Because the contraction time, measured with tensiomyography, reflects the individual's muscle fibre composition, our findings may reflect a shift from type I fibres to type II fibres in the GM muscles of PAD patients. Our data support the idea that calf myopathy is present in claudication-prone patients and, in part, determines the clinical manifestations of PAD. (C) 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.