Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer's Disease.
Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer's Disease.
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DOI：
10.3390/ijms222111677
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发表时间：
2021-10-28
影响因子：
5.6
通讯作者：
Strosznajder JB
中科院分区：
文献类型：
--
作者：
Czapski GA;Strosznajder JB
在阿尔茨海默病（AD）中，大脑中兴奋和抑制之间的生理平衡受到显著影响。几种神经活性化合物及其通过各种类型受体的信号传导途径在大脑内稳态中至关重要，其中包括谷氨酸和γ-氨基丁酸（GABA）。小胶质细胞受体的激活调节这些细胞的免疫反应，这在AD中可能是神经保护性或神经毒性的。新的研究方法揭示了小胶质细胞功能的复杂性，包括在神经炎症和AD大脑中与其他细胞的相互作用。这篇综述的目的是描述几种蛋白质和多种受体对小胶质细胞和神经元的作用，以及它们参与细胞之间的通信网络，可能导致不同的代谢循环和细胞死亡/存活。本文主要就谷氨酸能、GABA能信号在AD和神经炎症中小胶质细胞-神经元串扰中的作用作一综述。此外，AD相关的神经毒性蛋白在谷氨酸/GABA介导的小胶质细胞和神经元之间的对话中的意义进行了分析，以寻找神经保护的新靶点和先进的药理学方法。
The physiological balance between excitation and inhibition in the brain is significantly affected in Alzheimer’s disease (AD). Several neuroactive compounds and their signaling pathways through various types of receptors are crucial in brain homeostasis, among them glutamate and γ-aminobutyric acid (GABA). Activation of microglial receptors regulates the immunological response of these cells, which in AD could be neuroprotective or neurotoxic. The novel research approaches revealed the complexity of microglial function, including the interplay with other cells during neuroinflammation and in the AD brain. The purpose of this review is to describe the role of several proteins and multiple receptors on microglia and neurons, and their involvement in a communication network between cells that could lead to different metabolic loops and cell death/survival. Our review is focused on the role of glutamatergic, GABAergic signaling in microglia–neuronal cross-talk in AD and neuroinflammation. Moreover, the significance of AD-related neurotoxic proteins in glutamate/GABA-mediated dialogue between microglia and neurons was analyzed in search of novel targets in neuroprotection, and advanced pharmacological approaches.
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影响因子：
3.7
作者：
Chen S;Wang JM;Irwin RW;Yao J;Liu L;Brinton RD
通讯作者：
Brinton RD
二甲双胍可改善脂多糖引起的抑郁样行为和异常谷氨酸传递。
影响因子：
4.2
作者：
Chen J;Zhou T;Guo AM;Chen WB;Lin D;Liu ZY;Fei EK
通讯作者：
Fei EK
DOI：
10.1016/j.jalz.2010.12.014
发表时间：
2011-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Breitner JC;Baker LD;Montine TJ;Meinert CL;Lyketsos CG;Ashe KH;Brandt J;Craft S;Evans DE;Green RC;Ismail MS;Martin BK;Mullan MJ;Sabbagh M;Tariot PN;ADAPT Research Group
通讯作者：
ADAPT Research Group
影响因子：
12.7
作者：
Boza-Serrano, Antonio;Ruiz, Rocio;Deierborg, Tomas
通讯作者：
Deierborg, Tomas
影响因子：
6.4
作者：
Bertram, Lars;Tanzi, Rudolph E.
通讯作者：
Tanzi, Rudolph E.