A U-shaped relationship between alcohol consumption and cardiometabolic index in middle-aged men.
A U-shaped relationship between alcohol consumption and cardiometabolic index in middle-aged men.
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DOI：
10.1186/s12944-016-0217-4
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发表时间：
2016-03-09
影响因子：
4.5
通讯作者：
Wakabayashi I
中科院分区：
文献类型：
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作者：
Wakabayashi I
心脏代谢指数（CMI）是一项新的糖尿病鉴别指标。本研究的目的是确定CMI是否受到习惯性饮酒的影响。研究对象为21572名男性（35-60岁），每年接受健康检查。根据平均每日酒精摄入量将他们分为非饮酒者、轻度饮酒者（<22 g）、中度饮酒者（≥22 g且< 44 g）、重度饮酒者（≥44 g且< 66 g）和重度饮酒者（≥66 g）。酒精摄入量和CMI之间的关系进行了调查，调整了年龄和吸烟史和定期锻炼。对数转换的CMI显着低于轻，中度和重度饮酒者比非饮酒者，是最低的轻度饮酒者，而非饮酒者和非常重度饮酒者的对数转换的CMI没有显着差异。与非饮酒者相比，轻度、中度和重度饮酒者高CMI的比值比显著低于参考水平1.00，轻度饮酒者最低，但与重度饮酒者的参考水平无显著差异。高血糖的受试者与不高CMI的受试者的比值比在所有酒精组中均显著高于参考水平，在中度饮酒者中显著低于参考水平，但在其他饮酒者组中与非饮酒者组相比无显著差异。饮酒与CMI之间存在U型关系，适量饮酒（而非过量饮酒）可减弱CMI与高血糖之间的关联。
Cardiometabolic index (CMI) is a new index for discriminating diabetes. The purpose of this study was to determine whether CMI is affected by habitual alcohol drinking. The subjects were 21572 men (35-60 years) receiving annual health checkups. They were divided by average daily ethanol consumption into non-, light (<22 g), moderate (≥22 and < 44 g), heavy (≥44 and < 66 g) and very heavy (≥66 g) drinkers. Relationship between alcohol intake and CMI was investigated with adjustment for age and histories of smoking and regular exercise. Log-transformed CMI was significantly lower in light, moderate and heavy drinkers than in nondrinkers and was lowest in light drinkers, while there was no significant difference in log-transformed CMI of nondrinkers and very heavy drinkers. Odds ratio vs. nondrinkers for high CMI was significantly lower than the reference level of 1.00 in light, moderate and heavy drinkers and was lowest in light drinkers but was not significantly different from the reference level in very heavy drinkers. Odds ratio of subjects with vs. those without high CMI for hyperglycemia was significantly higher than the reference level in all of the alcohol groups and was significantly lower in moderate drinkers but was not significantly different in the other drinker groups when compared with the nondrinker group. There is a U-shaped relationship between alcohol consumption and CMI, and moderate drinking but not excessive drinking attenuates the association between CMI and hyperglycemia.