Influence of three anesthetic protocols on glomerular filtration rate in dogs
Influence of three anesthetic protocols on glomerular filtration rate in dogs
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DOI：
10.2460/ajvr.68.8.807
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发表时间：
2007-08-01
影响因子：
1
通讯作者：
Gogny, Marc
中科院分区：
文献类型：
--
作者：
Fusellier, Marion;Desfontis, Jean-Claude;Gogny, Marc
目的：观察美托咪定麻醉下清醒状态下临床正常犬的肾功能；噻嗪、氯胺酮和氟烷（XKH）组合；或异丙酚。动物——10只成年雌性比格犬。程序-每隔15天给狗服用美托咪辛（0.05 mg/kg， IV）；XKH组合（噻嗪[1mg /kg，静脉注射]、氯胺酮[5mg /kg，静脉注射]、氟烷[1%潮汐浓度]）；或异丙酚（6mg /kg，静脉）诱导麻醉或不治疗。肾小球滤过率的评估基于肾摄取（RU；通过肾显像测定）和血浆对锝99m标记的二乙烯三胺五乙酸（(99)mTc-DTPA）的清除率（CL）。结果：清醒犬平均+/- SEM RU为9.7 +/- 0.4%，CL为3.86 +/- 0.23 mL/min/kg。给药XKH （RU, 11.4 +/- 0.9%； CL, 4.6 +/- 0,32 mL/min/kg）或异丙酚（RU, 9.7 +/- 0.3%； CL, 3.78 +/- 0.37 mL/min/kg）对（99）mTc-DTPA的肾摄取和CL没有显著影响。xkh麻醉犬血浆（99）mTc-DTPA半衰期消除时间较清醒犬显著降低（分别为14.4 min和28.9 min）。然而，给予美托咪定后，肾小球滤过率显著降低（RU, 3.9 +/- 0.1%），达到最大肾活动的时间显著增加（867 +/- 56秒，而未麻醉时为181 +/- 11秒）。结论和临床意义：结果表明，异丙酚麻醉或XKH联合麻醉对健康beagle的肾功能没有影响，但美托咪定麻醉可降低（99）mTc-DTPA的早期RU。
Objective-To investigate renal function in clinically normal dogs when awake and during anesthesia with medetomidine; xylazine, ketamine, and halothane (XKH) combination; or propofol.Animals-10 adult female Beagles.Procedures-At intervals of 15 days, dogs were administered medetomicine (0.05 mg/kg, IV); XKH combination (xylazine [1 mg/kg, IV], ketamine [5 mg/kg, IV], and halothane [1% en-tidal concentration]); or propofol (6 mg/kg, IV) to induce anesthesia or no treatment. Glomerular filtration rate was assessed on the basis of renal uptake (RU; determined via renal scintigraphy) and plasma clearance (CL) of technetium 99m-labeled diethylenetriamine peentaacetic acid ((99)mTc-DTPA).Results-In awake dogs, mean +/- SEM RU was 9.7 +/- 0.4% and CL was 3.86 +/- 0.23 mL/min/kg. Renal uptake and CL of (99)mTc-DTPA were not significantly modified by administration of XKH (RU, 11.4 +/- 0.9%; CL, 4.6 +/- 0,32 mL/min/kg) or propofol (RU, 9.7 +/- 0.3%; CL, 3.78 +/- 0.37 mL/min/kg). Half-life elimination time of plasma (99)mTc-DTPA decreased significantly in XKH-anesthetized dogs, compared with the value in awake dogs (14.4 minutes and 28.9 minutes, respectively). However, glomerular filtration rate was significantly decreased by administration of medetomidine (RU, 3.9 +/- 0.1%), and the time to maximum kidney activity was significantly increased (867 +/- 56 seconds vs 181 +/- 11 seconds without anesthesia).Conclusions and Clinical Relevance-Results indicated that anesthesia with propofol or an XKH combination did not alter renal function in healthy Beagles, but anesthesia with medetomidine decreased early RU of (99)mTc-DTPA.