Regulation of T cells by mTOR: the known knowns and the known unknowns.
Regulation of T cells by mTOR: the known knowns and the known unknowns.
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DOI：
10.1016/j.it.2014.11.005
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发表时间：
2015-01
影响因子：
16.8
通讯作者：
Powell JD
中科院分区：
文献类型：
--
作者：
Pollizzi KN;Powell JD
哺乳动物/机械靶标雷帕霉素(MTOR)是一种重要的环境信号整合因子，对调节T细胞的激活、分化和功能至关重要。最近的研究利用药物抑制或T细胞特异性基因删除mTOR途径中的信号成分，为相关机制提供了重要的见解，并在确定mTOR下游促进免疫调节的靶点方面提供了信息。然而，这些研究也提出了令人困惑的、有时相互矛盾的发现，突显了在不同背景下研究mTOR途径的复杂性。在这里，我们回顾了目前对mTOR在T细胞生物学中的作用的理解，重点介绍了mTOR的新概念和研究领域，其中mTOR的确切作用尚未得到充分认识。
Mammalian/mechanistic target of rapamycin (mTOR) is emerging as an important integrator of environmental cues critical for the regulation of T cell activation, differentiation and function. Recent studies leveraging pharmacologic inhibition or T cell specific genetic deletion of signaling components in the mTOR pathway have provided important insights into the mechanisms involved, and have been informative in defining targets downstream of mTOR that promote immune regulation. However, these studies have also presented confusing and at times contradictory findings, highlighting the complexities involved in examining the mTOR pathway in distinct contexts. Here we review the current understanding of the roles of mTOR in T cell biology, highlighting emerging concepts and areas of investigation where the precise role of mTOR has yet to be fully discerned.
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影响因子：
5.4
作者：
Chang, Xing;Lazorchak, Adam S.;Liu, Dou;Su, Bing
通讯作者：
Su, Bing
影响因子：
4.3
作者：
Jung, Unsu;Foley, Jason E.;Fowler, Daniel H.
通讯作者：
Fowler, Daniel H.
DOI：
10.4049/jimmunol.1001176
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ferrer IR;Wagener ME;Robertson JM;Turner AP;Araki K;Ahmed R;Kirk AD;Larsen CP;Ford ML
通讯作者：
Ford ML
影响因子：
64.8
作者：
Araki, Koichi;Turner, Alexandra P.;Shaffer, Virginia Oliva;Gangappa, Shivaprakash;Keller, Susanne A.;Bachmann, Martin F.;Larsen, Christian P.;Ahmed, Rafi
通讯作者：
Ahmed, Rafi
影响因子：
3.7
作者：
He S;Kato K;Jiang J;Wahl DR;Mineishi S;Fisher EM;Murasko DM;Glick GD;Zhang Y
通讯作者：
Zhang Y