Inflammasomes: sensors of metabolic stresses for vascular inflammation.
Inflammasomes: sensors of metabolic stresses for vascular inflammation.
复制标题
炎症：用于血管炎症的代谢应力传感器。
DOI：
10.2741/4127
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Yang XF
中科院分区：
文献类型：
--
作者：
Yin Y;Pastrana JL;Li X;Huang X;Mallilankaraman K;Choi ET;Madesh M;Wang H;Yang XF
代谢综合征是西方世界的一个主要健康问题。患有代谢性疾病（例如 2 型糖尿病和肥胖症）的患者经常会发现促炎状态升高。动脉粥样硬化是与脉管系统相关的促炎状态的临床表现之一。在发现炎症体蛋白复合物之前，代谢应激诱导这种促炎症状态并促进动脉粥样硬化形成的确切机制仍然难以捉摸。该复合物由 caspase-1 前体和病原体传感器组成。炎症小体的激活需要炎症小体成分和翻译后组装的转录上调。已经提出了三种炎症小体组装模型：1）离子通道模型； 2）活性氧（ROS）模型； 3）溶酶体模型。无论哪种情况，炎症小体激活都会触发 caspase-1 前体自动激活至其成熟形式。 Caspase-1 最初作为 IL-1β 转换酶被发现，是炎症和细胞死亡途径的主要参与者。实验证明许多内源性代谢配体可以激活炎症小体，从而启动随后的炎症过程。进一步了解代谢配体激活炎症小体的独特分子机制可能有助于开发针对动脉粥样硬化和与代谢疾病相关的其他临床问题的新型治疗干预措施。
Metabolic syndrome is a major health issue in the western world. An elevated pro-inflammatory state is often found in patients with metabolic diseases such as type 2 diabetes and obesity. Atherosclerosis is one such clinical manifestation of pro-inflammatory state associated with the vasculature. The exact mechanism by which metabolic stress induces this pro-inflammatory status and promotes atherogenesis remained elusive until the discovery of the inflammasome protein complex. This complex is composed of pro-caspase-1 and pathogen sensors. Activation of inflammasome requires the transcriptional upregulation of inflammasome components and the post-translational assembly. Three models of inflammasome assembly have been proposed: 1) the ion channel model; 2) the reactive oxygen species (ROS) model; and 3) the lysosome model. In either case, inflammasome activation triggers the auto-activation of pro-caspase-1 into its mature form. Caspase-1, which was first discovered as the IL-1β converting enzyme, is known to be a major player in inflammatory and cell death pathways. Many endogenous metabolic ligands have been experimentally shown to activate inflammasome, and thus initiate the subsequent inflammation process. Further understanding of the distinct molecular mechanism by which metabolic ligands activates inflammasome could lead to developing novel therapeutic interventions for atherosclerosis and other clinical problems related to metabolic diseases.
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影响因子：
8.7
作者：
Galea, J;Armstrong, J;Holt, CM
通讯作者：
Holt, CM
DOI：
10.1161/01.atv.0000127025.48140.a3
发表时间：
2004-06-01
影响因子：
8.7
作者：
Isoda, K;Sawada, S;Ohsuzu, F
通讯作者：
Ohsuzu, F
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
5.4
作者：
Hornung, Veit;Latz, Eicke
通讯作者：
Latz, Eicke
影响因子：
56.9
作者：
Dostert, Catherine;Petrilli, Virginie;Tschopp, Jurg
通讯作者：
Tschopp, Jurg