THE COLLABORATIVE LIPID RESEARCH CLINICS FAMILY STUDY BIOLOGICAL AND CULTURAL DETERMINANTS OF FAMILIAL RESEMBLANCE FOR PLASMA LIPIDS AND LIPOPROTEINS
THE COLLABORATIVE LIPID RESEARCH CLINICS FAMILY STUDY BIOLOGICAL AND CULTURAL DETERMINANTS OF FAMILIAL RESEMBLANCE FOR PLASMA LIPIDS AND LIPOPROTEINS
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DOI：
10.1002/gepi.1370020302
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发表时间：
1985-01-01
影响因子：
2.1
通讯作者：
RIFKIND B M
中科院分区：
文献类型：
--
作者：
NAMBOODIRI K K;KAPLAN E B;RIFKIND B M
本文通过使用通用线性模型在1975 - 1978年收集的随机选择的家庭数据上，使用一般线性模型在1975 - 1978年收集的一般线性模型上报告了总计，LDL和HDL胆固醇和甘油三酸酯（TC，LDL-C，HDL-C，TG）水平的生物学和文化决定因素（TC，LDL-C，HDL-C，TG）水平。九个北美脂质研究诊所。最初，分析是针对临床特异性的，可以评估遗传和文化传播，婚姻相似性以及这些特征的其他决定因素的重要性，然后共同确定诊所诊所之间任何异质性的性质和来源。在大多数诊所中，所有特征都有明显的遗传和文化因素的证据。临床异质性也很重要，但不包括一个临床可以大大降低异质性。其余八个诊所的遗传（H2）和文化（C2）遗产均具有同质性，其汇总估计为H2为.556。+ - 。 .028，.539。+ - 。 .028，.485。+ - 。 .029和.358。+ - 。 .028和.029。+ - 的C2。 .006，.033。+ - 。 .006，.075。+ - 。 .008和.089。+ - 。 .009分别为TC，LDL-C，HDL-C和TG。在这些特征中，HDL-C在诊所之间表现出最大的差异，HDL-C和TG都表现出Larges的文化遗传力。讨论了这些和类似研究在对血浆脂质和脂蛋白决定因素的更广泛理解中的相关性。
This paper reports on the biological and cultural determinants of total, LDL, and HDL cholesterol, and triglyceride (TC, LDL-C, HDL-C, TG) levels using a general linear model on randomly selected family data collected during 1975-1978 at nine North American Lipid Research Clinics. Initially, the analyses were clinic-specific to assess the importance of genetic and cultural transmission, marital resemblance, and other determinants of these traits and then were made jointly to identify the nature and sources of any heterogeneity between clinics. There was evidence of significant genetic and cultural factors for all traits in most clinics. Clinic heterogeneity was also significant, but excluding one clinic reduced the heterogeneity considerably. The genetic (h2) and cultural (c2) heritabilities for the remaining eight clinics were homogeneous with pooled estimates of h2 of .556 .+-. .028, .539 .+-. .028, .485 .+-. .029, and .358 .+-. .028, and of c2 of .029 .+-. .006, .033 .+-. .006, .075 .+-. .008, and .089 .+-. .009 for TC, LDL-C, HDL-C, and TG, respectively. Among the traits, HDL-C exhibited the most difference among clinics, and both HDL-C and TG showed the larges cultural heritability. The relevance of these and similar studies in a broader understanding of the determinants of plasma lipids and lipoproteins is discussed.