Prevalence, genotyping, and correlates of anogenital HPV infection in a population-based sample of women in Puerto Rico.
Prevalence, genotyping, and correlates of anogenital HPV infection in a population-based sample of women in Puerto Rico.
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DOI：
10.1016/j.pvr.2016.04.002
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发表时间：
2016-12
期刊：
影响因子：
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通讯作者：
Palefsky J
中科院分区：
文献类型：
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作者：
Ortiz AP;Romaguera J;Pérez CM;González D;Muñoz C;González L;Marrero E;Tortolero-Luna G;Suárez E;Palefsky J
Oncogenic HPV infection is associated to anogenital cancer. We estimate the prevalence and correlates of anogenital HPV infection among a population-based sample of women aged 16–64 years living in the metropolitan area of Puerto Rico. 564 women completed face-to-face and computer assisted interviews and self-collected anal and cervical specimens. HPV DNA testing used MY09/MY11 consensus HPV L1 primers and beta-globin as an internal control for sample amplification. Positive specimens were typed by dot-blot hybridization. Weighted prevalence of cervical, anal, and cervical/anal co-infection was 29.4%, 38.6%, and 17.1%, respectively. The commonest oncogenic HPV types detected in the cervix and anus were: 68 (8% vs. 7%) and 16 (5.5% vs. 5.1%), correspondingly. Having ≥3 lifetime sexual partners (OR: 2.3; 95% CI: 1.5–3.5) and last year anal intercourse (OR: 1.6; 95% CI: 1.1–2.5) increased the odds of anogenital HPV infection. Cervical infection was independently associated to anal infection (OR: 3.0; 95% CI: 2.0–4.6). Similar to others, our results confirm the burden of anogenital HPV infection in women and its relationship with sexual behavior. As vaccination increases, future studies should monitor changing trends in HPV infection in this population, and the relationship between anal and cervical HPV-related disease.
