Effect of caffeine exposure during pregnancy on birth weight and gestational
Effect of caffeine exposure during pregnancy on birth weight and gestational
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DOI：
10.1093/aje/155.5.429
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发表时间：
2002-03-01
影响因子：
5
通讯作者：
Cnattingius, S
中科院分区：
文献类型：
--
作者：
Clausson, B;Granath, F;Cnattingius, S
流行病学研究一直无法最终评估怀孕期间摄入咖啡因是否与出生体重减轻和/或胎儿生长受限有关。作者进行了一项基于人群的前瞻性队列研究，以调查咖啡因对出生体重、胎龄和以胎龄为标准的出生体重(出生体重比)的影响。从1996年到1998年，在瑞典乌普萨拉县招募的953名早孕妇女中，有873名分娩活产单胎婴儿的妇女被纳入分析范围。在怀孕6-12周和32-34周时，通过面对面访谈确定咖啡因的暴露情况，并分析母亲血浆中可替宁水平，作为吸烟的指标。使用方差分析来估计咖啡因对出生体重、出生时胎龄和出生体重比的影响，在考虑了其他协变量的影响后，如母亲的社会人口学特征、血浆可替宁和怀孕症状。咖啡因摄入量与出生体重、胎龄和出生体重比之间没有相关性，无论是当咖啡因摄入量从怀孕到第32至34周的平均水平，还是当咖啡因摄入量按怀孕三个月分层时都是如此。这些结果不支持适度摄入咖啡因与出生体重、胎龄或胎儿生长减少之间的联系。
Epidemiologic studies have been unable to conclusively evaluate whether caffeine intake during pregnancy is associated with reduced birth weight and/or fetal growth restriction. The authors conducted a prospective, population-based cohort study to investigate the effect of caffeine on birth weight, gestational age, and birth weight standardized for gestational age (birth weight ratio). Of 953 women recruited in early pregnancy in Uppsala County, Sweden, from 1996 to 1998, 873 women delivering liveborn singleton infants were included in the analysis. Caffeine exposures were ascertained from in-person interviews at 6-12 and 32-34 completed gestational weeks, and maternal plasma was analyzed for cotinine levels as an indicator of smoking. Analysis of variance was used to estimate the effect of caffeine on birth weight, gestational age at delivery, and birth weight ratio after accounting for the effects of other covariates, such as maternal sociodemographic characteristics, plasma cotinine, and pregnancy symptoms. There were no associations between caffeine consumption and birth weight, gestational age, and birth weight ratio, neither when caffeine exposure was averaged from conception to the 32nd to 34th gestational weeks, nor when caffeine exposure was stratified by trimesters of pregnancy. These results do not support an association between moderate caffeine consumption and reduced birth weight, gestational age, or fetal growth.