Temporal and frequency characteristics of cartwheel cells in the dorsal cochlear nucleus of the awake mouse.
Temporal and frequency characteristics of cartwheel cells in the dorsal cochlear nucleus of the awake mouse.
复制标题
清醒小鼠耳蜗背核中侧手翻细胞的时间和频率特征。
DOI：
10.1152/jn.01356.2006
复制
发表时间：
2007
影响因子：
2.5
通讯作者：
Roberts,PatrickD
中科院分区：
文献类型：
--
作者：
Portfors,ChristineV;Roberts,PatrickD
耳蜗背核（DCN）是中枢听觉处理的起始部位，也是听觉通路中多感觉汇聚的第一个部位。听觉神经对 DCN 中主细胞的反应赋予音调频率组织。侧手翻细胞会改变主细胞的反应，但它们不接受直接的听觉神经输入。这项研究表明，侧手翻细胞对清醒小鼠的音调刺激反应良好，并且它们具有明确的特征频率，与 DCN 的音调组织相对应。侧手翻细胞的听觉反应表现出对音调的复杂频谱时间反应，刺激和抑制在刺激开始后在频率和时间上调节放电模式。对最佳频率音调的时间反应在侧手翻细胞之间变化很大，但使用一个简单的模型将这种变化统一为突触电流时间的差异。侧手翻细胞对双音刺激的反应表明，不同频率的相互作用会影响侧手翻细胞的输出。结果表明，在这种主要听觉结构中，对一个频率的声音的处理可以通过不同频率的声音来修改。侧手翻细胞中这些复杂的频率和时间相互作用表明这些神经元在基本的声音处理中发挥着积极的作用。
The dorsal cochlear nucleus (DCN) is an initial site of central auditory processing and also the first site of multisensory convergence in the auditory pathway. The auditory nerve imparts a tonotopic frequency organization on the responses of principal cells in the DCN. Cartwheel cells modify the responses of principal cells, but they do not receive direct auditory nerve input. This study shows that cartwheel cells respond well to tonal stimuli in the awake mouse and they have a well-defined characteristic frequency that corresponds to the tonotopic organization of the DCN. The auditory responses of cartwheel cells exhibit complex spectrotemporal responses to tones, with excitation and inhibition modulating the firing patterns in both frequency and time after onset of the stimulus. Temporal responses to best-frequency tones are highly variable between cartwheel cells, but a simple model is used to unify this variability as differences in the timing of synaptic currents. Cartwheel cell responses to two-tone stimuli show that interactions from different frequencies affect the output of cartwheel cells. The results suggest that at this primary auditory structure, processing of sound at one frequency can be modified by sounds of different frequency. These complex frequency and temporal interactions in cartwheel cells suggest that these neurons play an active role in basic sound processing.