Structural asymmetries in the human forebrain and the forebrain of non-human primates and rats
Structural asymmetries in the human forebrain and the forebrain of non-human primates and rats
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DOI：
10.1016/0149-7634(95)00072-0
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发表时间：
1996-12-01
影响因子：
8.2
通讯作者：
Steinmetz, H
中科院分区：
文献类型：
--
作者：
Zilles, K;Dabringhaus, A;Steinmetz, H
对下列结构可能的不对称性进行了研究：死后(未知利手)和活脑(男性右利手)的大脑总半球、皮质和白质体积；大鼠初级视觉皮质及其单眼和双眼亚区、第IV层的体积和第IV层有髓纤维的密度；大鼠皮质感觉运动区的递质受体密度(NMDA、AMPA、海人藻氨酸和GABA受体)；死后(未知利手)和活脑(男性右利手)的运动皮质体积和中央沟的3D范围；人类(男性左撇子和右撇子)和黑猩猩大脑中半球的花瓣。采用组织学、MRI和受体放射自显影技术。除了大鼠的递质受体和整个初级视觉皮质和黑猩猩的大脑半球没有表现出任何显著的方向性不对称外，所有研究的其他参数在左右半球之间都是不对称的。活体人脑中额叶和枕叶的区域分布模式和不对称程度在右撇子和左撇子之间是不同的。版权所有(C)1996爱思唯尔科学有限公司。
Possible asymmetries of the following structures were studied: volumes of total human hemispheres, cortex and white matter volumes in post-mortem- (unknown handedness) and living brains (male right-handers); volumes of the rat total primary visual cortex, its mon- and binocular subfields, its layer IV and the density of myelinated fibres in layer IV; transmitter receptor densities (NMDA, AMPA, kainate and GABA, receptors) in sensorimotor regions of the rat cortex; volume of the motor cortex and the 3D-extent of the central sulcus in the post-mortem- (unknown handedness) and living human brain (male right-handers); petalia of the hemispheres in human (male right- and left-handers) and chimpanzee brains. Histological, MRI and receptor autoradiographic techniques were used. With the notable exceptions of the transmitter receptors and the total primary visual cortex in rats and the hemispheres in chimpanzees, which do not show any significant directional asymmetry, all other parameters studied are asymmetrically distributed between the right- and left hemispheres. The regional distribution pattern and the degree of asymmetry of frontal and occipital petalia in living human brains differ between right- and left-handers. Copyright (C) 1996 Elsevier Science Ltd.