Characterization of childhood exposure to environmental contaminants using stool in a semi-urban middle-class cohort from eastern Canada.
Characterization of childhood exposure to environmental contaminants using stool in a semi-urban middle-class cohort from eastern Canada.
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DOI：
10.1016/j.envres.2023.115367
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发表时间：
2023-01
影响因子：
8.3
通讯作者：
Félix Hardy;L. Takser;Viginie Gillet;A. Baccarelli;J. Bellenger
中科院分区：
文献类型：
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作者：
Félix Hardy;L. Takser;Viginie Gillet;A. Baccarelli;J. Bellenger
儿童暴露于各种环境有机和无机污染物，对健康结果的影响在很大程度上仍然未知。许多矩阵（例如，血液、尿液、指甲、头发）已用于表征有机和无机污染物的暴露情况。粪便采样具有几个优点;它是非侵入性的，并提供了对肠道微生物暴露于污染物的直接评估。肠道微生物组是通过脑-肠轴神经发育的关键因素。它的组成和紊乱会影响儿童的神经发育。儿童暴露于污染物的表征通常是在脆弱人群中进行的（例如，来自发展中国家、低收入社区和大城市中心）。关于来自中产阶级、半城市和中等规模人口的儿童暴露于污染物的数据很少，尽管这些儿童占北美人口的很大一部分。在这项研究中，73种有机化合物从不同的化学类别和22种元素进行了分析，在6岁（n = 84）和10岁（n = 119）的儿童粪便从中产阶级，半城市，中等规模的人口队列从加拿大东部。结果表明，73种目标有机化合物中有67种和所有元素至少在一名儿童的粪便中检出。在超过25%的儿童粪便中仅检测到咖啡因（97%和80%）和对乙酰氨基酚（28%和48%），而在超过50%的儿童粪便中检测到除钛以外的所有元素。
Children are exposed to various environmental organic and inorganic contaminants with effects on health outcomes still largely unknown. Many matrices (e.g., blood, urine, nail, hair) have been used to characterize exposure to organic and inorganic contaminants. The sampling of feces presents several advantages; it is non-invasive and provides a direct evaluation of the gut microbiome exposure to contaminants. The gut microbiome is a key factor in neurological development through the brain-gut axis. Its composition and disturbances can affect the neurodevelopment of children. Characterization of children exposure to contaminants is often performed on vulnerable populations (e.g., from developing countries, low-income neighborhoods, and large urban centers). Data on the exposure of children from middle-class, semi-urban, and mid-size populations to contaminants is scarce despite representing a significant fraction of the population in North America. In this study, 73 organics compounds from different chemical classes and 22 elements were analyzed in 6 years old (n = 84) and 10 years old (n = 119) children's feces from a middle-class, semi-urban, mid-size population cohort from Eastern Canada. Results show that 67 out of 73 targeted organics compounds and all elements were at least detected in one child's feces. Only caffeine (97% & 80%) and acetaminophen (28% & 48%) were detected in more than 25% of the children's feces, whereas all elements besides titanium were detected in more than 50% of the children.