The prediction of novel multiple lipid-binding regions in protein translocation motor proteins: a possible general feature.
The prediction of novel multiple lipid-binding regions in protein translocation motor proteins: a possible general feature.
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DOI：
10.2478/s11658-010-0036-y
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发表时间：
2011-03
影响因子：
8.3
通讯作者：
Keller RC
中科院分区：
文献类型：
--
作者：
Keller RC
蛋白质转运是一个重要的细胞过程。SecA是SEC系统中必不可少的蛋白质成分，因为它含有促进蛋白质转位的分子马达。在这项研究中，生物信息学方法被应用于寻找蛋白质易位马达蛋白中可能的脂结合螺旋区域。在大肠杆菌SecA中发现了新的脂结合区。值得注意的是，在其他马达蛋白中也发现了多个脂结合位点，如参与ER蛋白转位的Bip。原核信号识别颗粒受体FtsY虽然不是一种运动蛋白，但在许多方面与SecA有关，因此被纳入本研究。这些结果显示了参与蛋白质转位的马达蛋白的一个可能的一般特征。本文的补充材料可通过10.2478/s11658-0100036-y获得，授权用户可访问。
Protein translocation is an important cellular process. SecA is an essential protein component in the Sec system, as it contains the molecular motor that facilitates protein translocation. In this study, a bioinformatics approach was applied in the search for possible lipid-binding helix regions in protein translocation motor proteins. Novel lipid-binding regions in Escherichia coli SecA were identified. Remarkably, multiple lipid-binding sites were also identified in other motor proteins such as BiP, which is involved in ER protein translocation. The prokaryotic signal recognition particle receptor FtsY, though not a motor protein, is in many ways related to SecA, and was therefore included in this study. The results demonstrate a possible general feature for motor proteins involved in protein translocation. Supplementary material is available for this article at 10.2478/s11658-010-0036-y and is accessible for authorized users.
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影响因子：
64.5
作者：
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通讯作者：
WICKNER, W
影响因子：
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作者：
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作者：
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通讯作者：
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