DISSEMINATED NECROTIZING LEUKOENCEPHALOPATHY
DISSEMINATED NECROTIZING LEUKOENCEPHALOPATHY
复制标题
播散性坏死性白质脑病
DOI：
10.1111/j.1440-1827.1980.tb01361.x
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发表时间：
1980
影响因子：
2.2
通讯作者：
Mitsunori Morimatsit
中科院分区：
文献类型：
--
作者：
Y. Nakazato;Y. Ishida;Mitsunori Morimatsit
A 30‐year‐old male with chronic myelogenous leukemia was treated by intrathecal instillation of methotrexate and cytosine arabinoside because of meningeal infiltration of leukemic cells. He developed neurological signs of bilateral cerebral dysfunction with progressive deterioration and died. The neuropathological changes consisted of multiple small areas of demyelination and coagulative necrosis that were randomly disseminated in the cerebral white matter. There was a remarkable decrease of glial nuclei and occasional deposits of mineral salts. Numerous axonal swellings were observed within and around the necrotizing foci. A moderate astrocytosis and mild status spongiosus were found in the surrounding white matter. The etiological relationship of these changes to intrathecal methotrexate is discussed.
