Lack of hippocampal volume change in long-term heavy cannabis users.
Lack of hippocampal volume change in long-term heavy cannabis users.
复制标题
长期大量吸食大麻的人海马体积缺乏变化。
DOI：
10.1080/10550490590899862
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Yurgelun-Todd,DeborahA
中科院分区：
文献类型：
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作者：
Tzilos,GolfoK;Cintron,ChristinaB;Wood,JonasBR;Simpson,NorahS;Young,AshleyD;PopeJr,HarrisonG;Yurgelun-Todd,DeborahA
吸食大麻对海马体形态的影响仍不清楚，特别是因为之前的人类研究主要检查的是年轻、短期吸食者。我们使用磁共振成像来研究一组 22 名老年长期大麻使用者（报告平均 [SD] 为 20,100 [13,900] 次终生吸烟事件）和 26 名没有大麻滥用或依赖史的对照受试者。与对照组相比，吸烟者的灰质、白质、脑脊液或左右海马体积没有显着调整差异。此外，大麻使用者的海马体积与开始使用大麻的年龄或终生使用的总次数无关。这些发现与最近的文献一致，表明大麻的使用与整个大脑或特别是海马体的结构变化无关。
The effects of cannabis smoking on the morphology of the hippocampus are still unclear, especially because previous human studies have examined primarily younger, shorter-term users. We used magnetic resonance imaging to investigate these effects in a group of 22 older, long-term cannabis users (reporting a mean [SD] of 20,100 [13,900] lifetime episodes of smoking) and 26 comparison subjects with no history of cannabis abuse or dependence. When compared to control subjects, smokers displayed no significant adjusted differences in volumes of gray matter, white matter, cerebrospinal fluid, or left and right hippocampus. Moreover, hippocampal volume in cannabis users was not associated with age of onset of use nor total lifetime episodes of use. These findings are consistent with recent literature suggesting that cannabis use is not associated with structural changes within the brain as a whole or the hippocampus in particular.