A Service-Based Framework for Pharmacogenomics Data Integration
A Service-Based Framework for Pharmacogenomics Data Integration
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DOI：
10.1080/17517575.2010.498525
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发表时间：
2009-10
期刊：
影响因子：
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通讯作者：
Kun Wang;Xiaoying Bai;Jing Li;Cong Ding
中科院分区：
文献类型：
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作者：
Kun Wang;Xiaoying Bai;Jing Li;Cong Ding
数据是药物基因组学研究和实践的核心。然而，由于数据格式、结构和语义上的异构性问题，使得对爆炸性增长的各种数据进行集成和综合分析变得困难。随着越来越多的公共数据库可以通过可编程接口和Web门户等标准协议访问，基于Web的数据集成成为管理和合成分布在各地的数据的主要趋势。本文提出了一个基于服务的框架来支持跨不同分布式数据库的查询，使得药物基因组研究人员对异质数据源是透明的。研究介绍了Mashup的概念和技术，用于对互联网上的多维数据和信息进行交叉查询和关联。
Data are central to pharmacogenomics research and practices. However, due to the heterogeneous problems in data formats, structures and semantics, it is hard to integrate the diversified data that grow explosively and analyze them comprehensively. As more and more public databases are accessible through standard protocols like programmable interfaces and Web portals, Web-based data integration becomes a major trend to manage and synthesize data which are distributed located. The paper proposes a service-based framework to enable queries across various distributed databases in a way that the pharmacogenomics researchers are transparent to the heterogeneous data sources. The research introduces the mashup concepts and technologies for cross-querying and correlating the multi-dimensional data and information over the Internet.