ANIMAL-MODELS FOR THE STUDY OF FETAL TISSUE-REPAIR
ANIMAL-MODELS FOR THE STUDY OF FETAL TISSUE-REPAIR
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DOI：
10.1016/0022-4804(91)90097-6
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发表时间：
1991-09-01
影响因子：
2.2
通讯作者：
LONGAKER, MT
中科院分区：
文献类型：
--
作者：
ADZICK, NS;LONGAKER, MT
最近的实验和临床证据表明，胎儿对损伤的反应方式与成人完全不同。急性炎症几乎总是不存在，透明质酸是伤口基质的重要成分，胶原蛋白以无疤痕的方式沉积。利用各种动物模型和技术，许多研究者已经开始分析胎儿伤口愈合过程的成分，试图了解赋予胎儿独特愈合能力的控制机制。由于疤痕和纤维化在几乎所有医学专业中都占主导地位，因此最终的临床目标是描述胎儿伤口愈合的生物学原理，然后将其应用于调节成人伤口愈合问题。
Recent experimental and clinical evidence suggests that the fetus responds to injury in a fashion fundamentally different from that of the adult. Acute inflammation is almost always absent, hyaluronic acid is a prominent component of the wound matrix, and collagen is deposited in a scarless manner. Using a variety of animal models and techniques, numerous investigators have begun to analyze the constituents of the fetal wound healing process in an attempt to understand the control mechanisms that endow the fetus with unique healing abilities. Since scarring and fibrosis dominate some diseases in almost every medical specialty, the ultimate clinical aim is to delineate the biological principles of fetal wound healing and then apply them to modulate adult wound healing problems.