Sex-related differences in bronchial parameters and pulmonary function test results in patients with chronic obstructive pulmonary disease based on three-dimensional quantitative computed tomography
Sex-related differences in bronchial parameters and pulmonary function test results in patients with chronic obstructive pulmonary disease based on three-dimensional quantitative computed tomography
复制标题
DOI：
10.1177/0300060517721309
复制
发表时间：
2018-01-01
影响因子：
1.6
通讯作者：
Guo, You-min
中科院分区：
文献类型：
--
作者：
Li, Yan;Dai, Yong-liang;Guo, You-min
目的 本研究旨在评估性别对支气管参数以及肺功能检测中以用力肺活量百分比表示的预计第1秒用力呼气量（FEV1%预计值）的影响。方法 回顾性分析359例有FEV1%预计值和计算机断层扫描（CT）图像的慢性阻塞性肺疾病（COPD）患者的数据。使用FACT - Digital lung TM软件（中国西安德信）对支气管进行全自动三维CT定量测量。测量第5至7级支气管，分析的参数包括管腔直径（LD）、管壁厚度（WT）、管腔面积（LA）以及WA%[WA/(WA + LA)×100%]。结果 在吸烟组、戒烟组和非吸烟组中，女性的WA%显著高于男性，而LD、WT和LA显著小于男性。在吸烟组和戒烟组中，女性的FEV1%预计值显著低于男性。在非吸烟组中，女性的FEV1%预计值显著高于男性。结论 性别相关差异可能部分解释了为什么在COPD患者中吸烟女性比男性经历更严重的肺功能损害。
Objective This study was performed to evaluate the effect of sex on bronchial parameters and the predicted forced expiratory volume in 1s expressed as a percentage of the forced vital capacity (FEV1% pred) on pulmonary function testing.Methods The data of 359 patients with chronic obstructive pulmonary disease (COPD) with available FEV1% pred and computed tomography (CT) images were retrospectively reviewed. FACT-Digital lung TM software (DeXin, Xi'an, China) was used to perform fully automated three-dimensional CT quantitative measurements of the bronchi. Generation 5 to 7 bronchi were measured, and the parameters analyzed were the lumen diameter (LD), wall thickness (WT), lumen area (LA), and WA% [WA/(WA+LA)x100%].Results In the smoking, smoking cessation, and nonsmoking groups, women had a significantly larger WA% and smaller LD, WT, and LA than men. The FEV1% pred was significantly lower in women than men in the smoking and smoking cessation groups. The FEV1% pred was significantly higher in women than men in the nonsmoking group.Conclusion Sex-related differences may partially explain why smoking women experience more severe pulmonary function impairment than men among patients with COPD.