A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas.

A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas.
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恶性寡头政治:祖细胞控制少突胶质细胞瘤的行为。

DOI:
10.1016/j.ccr.2010.11.031
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发表时间:
2010
期刊:
影响因子:
50.3
通讯作者:
Wechsler-Reya,RobertJ
Wechsler-Reya,RobertJ
中科院分区:
医学1区
文献类型:
--
作者:
Pei,Yanxin;Wechsler-Reya,RobertJ

文献摘要

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最近的研究表明,脑肿瘤起源于神经干细胞,并由干细胞样肿瘤起始细胞(TIC)维持。在这一期的《癌细胞》杂志上,报道少突胶质细胞瘤,不像恶性星形细胞瘤,起源于类似少突胶质细胞祖细胞的细胞,并由其繁殖。
Recent studies have suggested that brain tumors arise from neural stem cells and are maintained by stem-like tumor-initiating cells (TICs). In this issue ofCancer Cell, Persson et al. report that oligodendrogliomas, unlike malignant astrocytomas, originate from—and are propagated by—cells that resemble oligodendrocyte progenitors.