C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis
C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis
复制标题
DOI：
10.1016/j.mvr.2009.03.001
复制
发表时间：
2009-06-01
影响因子：
3.1
通讯作者：
Li Huiyun
中科院分区：
文献类型：
--
作者：
Zhao Jin;Chi Luxiang;Li Huiyun
几条证据支持ECE-1参与动脉粥样硬化疾病的发展。我们研究了ECE-1b基因C-338 A多态性与颈动脉粥样硬化的关系。对518例颈动脉粥样硬化患者和518例年龄、性别相匹配的对照者进行ECE-1b C-338 A基因多态性检测。颈动脉粥样硬化患者ECE-1b-338 A等位基因频率显著高于对照组（χ 2 = 9.167; P=0.002）。与C等位基因相比，A等位基因使颈动脉粥样硬化的危险性增加26%（OR=1.26，95% CI=1.05-1.52）。在分层分析中，携带A等位基因的基因型与女性（校正OR = 1.57; 95%CI = 1.14-2.23）和年龄：64岁的受试者（校正OR = 1.72; 95%CI = 1.23-1.41）颈动脉粥样硬化的风险增加显著相关。提示ECE-1b-338 A等位基因携带基因型可能与中国人群颈动脉粥样硬化的风险增加有关。皇冠版权所有（C）2009由爱思唯尔公司出版。All rights reserved.
Several lines of evidence supported the involvement of ECE-1 in the development of atherosclerosis disease. We investigated the C-338A polymorphism of the ECE-1b gene in carotid atherosclerosis. A cohort of 518 Chinese carotid atherosclerosis patients and 518 controls matched by age and sex were examined for the ECE-1b C-338A polymorphism. The ECE-1b-338 A allele was significantly frequent in carotid atherosclerosis patients than in controls (chi(2) = 9.167; P=0.002). A alleles had a 26% increased risk of carotid atherosclerosis compared with C alleles (OR=1.26; 95% CI=1.05-1.52). In stratified analyses, the A allele carrying genotypes was significantly associated with an increased risk of carotid atherosclerosis in females (adjusted OR = 1.57; 95% CI = 1.14-2.23) and a subject with age :64 years (adjusted OR = 1.72; 95% CI = 1.23-1.41). Our results suggested that ECE-1b-338 A allele carrying genotypes might be associated with increased risk of carotid atherosclerosis in the Chinese population. Crown Copyright (C) 2009 Published by Elsevier Inc. All rights reserved.