The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.
The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.
复制标题
活性位点异亮氨酸至丙氨酸突变对 DHFR 催化氢化物转移的影响。
DOI：
10.1039/c0cc02988b
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Kohen,Amnon
中科院分区：
文献类型：
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作者：
Stojković,Vanja;Perissinotti,LauraL;Lee,Jeeyeon;Benkovic,StephenJ;Kohen,Amnon
Comparison of the nature of hydride transfer in wild-type and active site mutant (I14A) of dihydrofolate reductase suggests that the size of this side chain at position 14 modulates H-tunneling.
