Genome function and nuclear architecture: from gene expression to nanoscience.
Genome function and nuclear architecture: from gene expression to nanoscience.
复制标题
基因组功能和核结构：从基因表达到纳米科学。
DOI：
10.1101/gr.946403
复制
发表时间：
2003
期刊：
影响因子：
7
通讯作者：
vanDriel,Roel
中科院分区：
文献类型：
--
作者：
O'Brien,TimothyP;Bult,CarolJ;Cremer,Christoph;Grunze,Michael;Knowles,BarbaraB;Langowski,Jorg;McNally,James;Pederson,Thoru;Politz,JoanC;Pombo,Ana;Schmahl,Gunter;Spatz,JoachimP;vanDriel,Roel
近年来，生物物理、化学和纳米科学方法在研究核结构和活性方面取得了很大的进展，并且前景看好。在这些新的视角和方法的背景下，回顾和讨论了基因组组织和功能中的一些基本问题。推进这些概念将需要物理学家、化学家和材料科学家与细胞、发育和基因组生物学家合作的协调网络。
Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.