Relationship of Gastrointestinal Symptoms and Psychosocial Distress to Gastric Retention in Children
Relationship of Gastrointestinal Symptoms and Psychosocial Distress to Gastric Retention in Children
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DOI：
10.1016/j.jpeds.2014.02.063
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发表时间：
2014-07-01
影响因子：
5.1
通讯作者：
Chumpitazi, Bruno P.
中科院分区：
文献类型：
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作者：
Wong, Gregory K.;Shulman, Robert J.;Chumpitazi, Bruno P.
目的 确定患有/不患有胃轻瘫的儿童之间胃肠道 (GI) 症状（腹痛、非疼痛性胃肠道症状、恶心）和/或社会心理困扰是否存在差异，以及胃肠道症状和/或心理社会困扰的严重程度是否与胃轻瘫的程度相关。研究设计 7-18 岁儿童（N = 100；63 名女性患者）接受 4 小时胃排空闪烁扫描研究，完成评估胃肠道症状的调查问卷，这项前瞻性研究的焦虑和躯体化。酌情使用 Spearman 相关性、Mann-Whitney、t 检验和 chi(2) 检验进行统计分析。结果 胃轻瘫儿童 (n = 25) 比排空正常的儿童年轻（12.6 +/- 3.5 比 14.3 +/- 2.6 岁，P = .01）。由于 7 至 10 岁儿童的问卷回答不一致，因此仅使用 11 至 18 岁儿童报告的症状。在这个年龄较大的组中（n = 83），胃轻瘫儿童（n = 17）在胃肠道症状或心理困扰的严重程度方面与排空正常的儿童没有差异。在胃轻瘫儿童中，4 小时胃潴留与呕吐 (r = -0.506，P = .038)、恶心 (r = -0.536，P = .019)、难以吃完饭 (r = -0.582，P = .014) 和儿童躯体化量表评分 (r = -0.544，P = .024) 呈负相关，并与有症状从睡眠中醒来的频率（r = 0.551，P = .022）。 结论 在接受胃排空闪烁扫描的患有/不患有胃轻瘫的儿童之间，胃肠道症状和心理社会困扰的严重程度没有差异。在胃轻瘫患者中，胃潴留似乎与消化不良症状和躯体化呈负相关，与从睡眠中醒来并出现症状呈正相关。
Objectives To determine whether gastrointestinal (GI) symptoms (abdominal pain, nonpain GI symptoms, nausea) and/or psychosocial distress differ between children with/without gastroparesis and whether the severity of GI symptoms and/or psychosocial distress is related to the degree of gastroparesis.Study design Children aged 7-18 years (N = 100; 63 female patients) undergoing a 4-hour gastric emptying scintigraphy study completed questionnaires evaluating GI symptoms, anxiety, and somatization for this prospective study. Spearman correlation, Mann-Whitney, t-test, and chi(2) tests were used as appropriate for statistical analysis.Results Children with gastroparesis (n = 25) were younger than those with normal emptying (12.6 +/- 3.5 vs 14.3 +/- 2.6 years, P = .01). Because questionnaire responses from 7- to 10-year-old children were inconsistent, only patient-reported symptoms from 11- to 18-year-olds were used. Within this older group (n = 83), children with gastroparesis (n = 17) did not differ from children with normal emptying in severity of GI symptoms or psychosocial distress. In children with gastroparesis, gastric retention at 4 hours was related inversely to vomiting (r = -0.506, P = .038), nausea (r = -0.536, P = .019), difficulty finishing a meal (r = -0.582, P = .014), and Children's Somatization Inventory score (r = -0.544, P = .024) and positively correlated with frequency of waking from sleep with symptoms (r = 0.551, P = .022).Conclusions The severity of GI symptoms and psychosocial distress do not differ between children with/without gastroparesis who are undergoing gastric emptying scintigraphy. In those with gastroparesis, gastric retention appears to be inversely related to dyspeptic symptoms and somatization and positively related to waking from sleep with symptoms.