Area under the curve as a tool to measure kinetics of tumor growth in experimental animals
Area under the curve as a tool to measure kinetics of tumor growth in experimental animals
复制标题
DOI：
10.1016/j.jim.2012.06.005
复制
发表时间：
2012-08-31
影响因子：
2.2
通讯作者：
Srivastava, Pramod K.
中科院分区：
文献类型：
--
作者：
Duan, Fei;Simeone, Shauna;Srivastava, Pramod K.
肿瘤直径或肿瘤体积的测量传统上用于定量和比较小鼠和大鼠中的肿瘤生长曲线。在这里，我们描述了使用曲线下面积（AUC）作为替代方法来做同样的事情。该单个数值（a）对于单个曲线容易获得，（B）通过单个数字反映整个肿瘤生长曲线，（c）可以容易地修改以获得生长曲线的限定部分的数据（例如，以确定稳定的疾病），以及（d）允许更容易地进行组间比较。使用来自大量活肿瘤细胞激发的小鼠的肿瘤生长数据，我们证明了这种工具在这些目的的常规方法上的实用性。(C)2012爱思唯尔有限公司版权所有。
Measurement of tumor diameters or tumor volumes has been traditionally used to quantitate and compare tumor growth curves in mice and rats. Here, we describe the use of area under the curve (AUC) as an alternative method to do the same. This single numerical value (a) is easy to obtain for individual curves, (b) reflects the entire tumor growth curve through a single number, (c) can be easily modified to obtain data for defined sections of the growth curve (for example, to determine stable disease), and (d) allows easier comparisons between groups. Using tumor growth data from a large number of mice challenged with live tumor cells, we demonstrate the utility of this tool over the conventional methods for these purposes. (C) 2012 Elsevier B.V. All rights reserved.