The Eastern Cooperative Oncology Group Performance Status as a prognostic factor of stage I–III colorectal cancer surgery for elderly patients: a multi-institutional retrospective analysis
The Eastern Cooperative Oncology Group Performance Status as a prognostic factor of stage I–III colorectal cancer surgery for elderly patients: a multi-institutional retrospective analysis
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东部肿瘤合作组的表现状况作为老年患者 I-III 期结直肠癌手术的预后因素：多机构回顾性分析
DOI：
10.1007/s00595-021-02412-4
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发表时间：
2022
期刊：
影响因子：
2.5
通讯作者：
K. Sugihara
中科院分区：
文献类型：
--
作者：
M. Hanaoka;H. Hino;A. Shiomi;H. Kagawa;S. Manabe;Y. Yamaoka;S. Kato;S. Yamauchi;Y. Kinugasa;K. Sugihara
接受根治性手术的老年结直肠癌（CRC）患者的一般状况与长期预后之间的关系尚不清楚。本研究调查了老年结直肠癌患者长期预后不良的危险因素。从日本研究组的多机构数据库中收集了接受根治性手术的≥ 80岁pStage I至III CRC患者的数据，用于CRC术后随访。我们回顾性研究了影响总生存期（OS）和无复发生存期（RFS）的不良预后因素。共研究了473例中位年龄为83岁的患者（东部肿瘤协作组体能状态[ECOG-PS]分别为315、121、34和3）。多因素考克斯回归分析显示，ECOG-PS ≥ 2和淋巴结转移阳性与OS差独立相关（均P <0.01）。阳性淋巴结转移（p <0.01）和肿瘤深度（T3或T4）（p = 0.02）与RFS差独立相关。在I期和II期患者中，而非III期患者中，ECOG-PS ≥ 2的患者的OS显著差于ECOG-PS ≤ 1的患者。术前ECOG-PS是老年结直肠癌患者根治性手术后的重要预后因素。
The relationship between the general condition and long-term prognosis in elderly patients with colorectal cancer (CRC) undergoing curative surgery remains unclear. This study investigated the risk factors for poor long-term outcomes in elderly patients with CRC. Data of pStage I to III patients with CRC ≥ 80 years old who underwent curative surgery were collected from a multi-institutional database of the Japanese study group for postoperative follow-up of CRC. We retrospectively investigated the poor prognostic factors for the overall survival (OS) and relapse-free survival (RFS). A total of 473 patients with a median age of 83 years were investigated (315, 121, 34, and 3 with an Eastern Cooperative Oncology Group Performance Status [ECOG-PS] 0, 1, 2, and 3, respectively). Multivariate Cox regression analysis showed that ECOG-PS ≥ 2 and positive lymph node metastasis were independently associated with a poor OS (both p < 0.01). Positive lymph node metastasis (p < 0.01) and tumor depth (T3 or T4) (p = 0.02) were independently associated with a poor RFS. In Stages I and II, but not Stage III patients, the OS was significantly worse in those with ECOG-PS ≥ 2 than in those with ECOG-PS ≤ 1. Preoperative ECOG-PS was a significant prognostic factor for elderly patients with CRC after curative surgery.
DOI：
10.1093/gerona/56.3.m146
发表时间：
2001-03-01
影响因子：
5.1
作者：
Fried, LP;Tangen, CM;McBurnie, MA
通讯作者：
McBurnie, MA