Search, capture and signal: games microtubules and centrosomes play.
Search, capture and signal: games microtubules and centrosomes play.
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DOI：
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发表时间：
2001-01
影响因子：
4
通讯作者：
S. C. Schuyler;David Pellman
中科院分区：
文献类型：
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作者：
S. C. Schuyler;David Pellman
染色体在分裂细胞中的准确分布需要细胞极性信号与有丝分裂纺锤体方向和细胞周期进程的耦合。对出芽酵母的研究表明，胞质动力蛋白和动力蛋白Kip3p定义了确保纺锤体定向的冗余途径。此外，研究表明Kip3p通路组分Kar9p和Bim1p （Yeb1p）形成一个复合体，在皮质极性信号和纺锤体微管之间提供分子连接。最近，其他研究表明Kar9p的皮质定位取决于肌动蛋白索和Myo2p（一种V型肌球蛋白）。此外，已经描述了一个依赖bub2的细胞周期检查点，该检查点抑制有丝分裂退出网络和细胞分裂，直到获得适当的中心体位置。结合起来，这些研究提供了细胞如何连接细胞极性，纺锤体位置和细胞周期进程的分子洞察力。
Accurate distribution of the chromosomes in dividing cells requires coupling of cellular polarity cues with both the orientation of the mitotic spindle and cell cycle progression. Work in budding yeast has demonstrated that cytoplasmic dynein and the kinesin Kip3p define redundant pathways that ensure proper spindle orientation. Furthermore, it has been shown that the Kip3p pathway components Kar9p and Bim1p (Yeb1p) form a complex that provides a molecular link between cortical polarity cues and spindle microtubules. Recently, other studies indicated that the cortical localization of Kar9p depends upon actin cables and Myo2p, a type V myosin. In addition, a BUB2-dependent cell cycle checkpoint has been described that inhibits the mitotic exit network and cytokinesis until proper centrosome position is achieved. Combined, these studies provide molecular insight into how cells link cellular polarity, spindle position and cell cycle progression.