Fatigue and depression predict reduced health-related quality of life in childhood-onset lupus.
Fatigue and depression predict reduced health-related quality of life in childhood-onset lupus.
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DOI：
10.1177/0961203317716317
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发表时间：
2018-01
期刊：
影响因子：
2.6
通讯作者：
Kashikar-Zuck S
中科院分区：
文献类型：
--
作者：
Donnelly C;Cunningham N;Jones JT;Ji L;Brunner HI;Kashikar-Zuck S
我们的目的是确定儿童期发病狼疮（cSLE）患者健康相关生活质量（HRQoL）持续降低的危险因素，并描述HRQoL持续降低的风险特征。在三级风湿病诊所，50例cSLE患者接受了两次评估，间隔约6个月。在每次访视时收集疾病活动性指标和患者报告的HRQoL、疼痛、抑郁症状、焦虑和残疾指标。在第1次和第2次访视时，分别有66%和56%的患者出现临床相关疲劳; 26%和24%的患者出现临床显著抑郁症状; 34%和28%的患者出现临床显著焦虑。首次访视时较高的疲劳和抑郁症状可显著预测随访时的POLICY HRQoL。使用疲劳和抑郁症状的临床相关临界值，将患者分配到低风险组（n=27）或高风险组（n=23）。在高风险组中观察到显著更大的疼痛、焦虑和应对困难。对cSLE青年患者的疲劳和情绪症状进行常规评估可能有助于识别持续性HRQoL不良的风险。整合行为干预，以解决疲劳和情绪症状的医疗护理，这类患者可能是有益的，但在这方面需要更多的研究。
We aimed to identify risk factors for persistently reduced health-related quality of life (HRQoL) in childhood-onset lupus (cSLE) and describe a risk profile for persistently reduced HRQoL. At a tertiary rheumatology clinic, 50 cSLE patients were assessed twice approximately six months apart. Measures of disease activity and patient-reported measures of HRQoL, pain, depressive symptoms, anxiety and disability were collected at each visit. At visit 1 and 2 respectively, clinically relevant fatigue was present in 66% and 56% of patients; clinically significant depressive symptoms in 26% and 24%; and clinically significant anxiety in 34% and 28%. Poorer HRQoL at follow-up was significantly predicted by higher fatigue and depressive symptoms at the initial visit. Using clinically relevant cutoffs for fatigue and depressive symptoms, patients were assigned to Low (n=27) or High Risk (n=23) groups. A profile of significantly greater pain, anxiety and coping difficulties was seen in the High Risk group. Routine assessment of fatigue and mood symptoms in youth with cSLE could be helpful in identifying those at risk for persistently poor HRQoL. Integration of behavioral interventions to address fatigue and mood symptoms into medical care for such patients may be beneficial but more research in this area is needed.
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影响因子：
4.7
作者：
Lootens, Catrina C.;Rapoff, Michael A.
通讯作者：
Rapoff, Michael A.
DOI：
10.1097/chi.0b013e3180592aaa
发表时间：
2007-11-01
影响因子：
13.3
作者：
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影响因子：
2.9
作者：
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通讯作者：
Richards, Margaret M.
影响因子：
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作者：
Julian, Laura J.;Yelin, Edward;Yazdany, Jinoos;Panopalis, Pantelis;Trupin, Laura;Criswell, Lindsey A.;Katz, Patricia
通讯作者：
Katz, Patricia
影响因子：
2.9
作者：
Keller, S;Bann, CM;Cleeland, CS
通讯作者：
Cleeland, CS