Fungal-mediated consolidated bioprocessing: the potential of Fusarium oxysporum for the lignocellulosic ethanol industry.
Fungal-mediated consolidated bioprocessing: the potential of Fusarium oxysporum for the lignocellulosic ethanol industry.
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DOI：
10.1186/s13568-016-0185-0
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发表时间：
2016-03
期刊：
影响因子：
3.7
通讯作者：
Doohan FM
中科院分区：
文献类型：
--
作者：
Ali SS;Nugent B;Mullins E;Doohan FM
从底物分解代谢的角度来看，微生物将木质纤维素加工成生物乙醇仍然是一个挑战。最重要的挑战是克服底物的阻力，从而减少生物精制木质纤维素所需的步骤。传统上，转化包括木质纤维素的化学预处理，然后将生物质水解成单体糖，然后发酵成生物乙醇。联合生物处理(CBP)被认为是一种以木质纤维素为原料生产生物乙醇的高效、经济的方法。CBP将水解和发酵步骤整合到一个过程中，从而显著减少了生物精炼过程中的步骤数量。丝状真菌是一种非凡的有机体，天生擅长分解植物的生物量，因此它们作为CBP的组成部分具有巨大的潜力。真菌尖孢镰刀菌具有将木质纤维CBP转化为生物乙醇的潜力。本文讨论了CBP的复杂性和潜力、过程中的瓶颈，以及真菌遗传多样性、底物复杂性和新技术对木质纤维素CPB效果的潜在影响，重点讨论了尖孢镰刀菌。
Microbial bioprocessing of lignocellulose to bioethanol still poses challenges in terms of substrate catabolism. The most important challenge is to overcome substrate recalcitrance and to thus reduce the number of steps needed to biorefine lignocellulose. Conventionally, conversion involves chemical pretreatment of lignocellulose, followed by hydrolysis of biomass to monomer sugars that are subsequently fermented into bioethanol. Consolidated bioprocessing (CBP) has been suggested as an efficient and economical method of manufacturing bioethanol from lignocellulose. CBP integrates the hydrolysis and fermentation steps into a single process, thereby significantly reducing the amount of steps in the biorefining process. Filamentous fungi are remarkable organisms that are naturally specialised in deconstructing plant biomass and thus they have tremendous potential as components of CBP. The fungus Fusarium oxysporum has potential for CBP of lignocellulose to bioethanol. Here we discuss the complexity and potential of CBP, the bottlenecks in the process, and the potential influence of fungal genetic diversity, substrate complexity and new technologies on the efficacy of CPB of lignocellulose, with a focus on F. oxysporum.