Pulsed Doppler echocardiographic study of left ventricular filling in dilated cardiomyopathy.
Pulsed Doppler echocardiographic study of left ventricular filling in dilated cardiomyopathy.
复制标题
扩张型心肌病左心室充盈的脉冲多普勒超声心动图研究。
DOI：
10.1016/0002-9149(86)90258-4
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
W. Henry
中科院分区：
文献类型：
--
作者：
K. Takenaka;A. Dabestani;J. Gardin;Daniel Russell;S. Clark;A. Allfie;W. Henry
据报道，扩张型心肌病 (DC) 患者左心室 (LV) 舒张特性异常。为了评估 DC 患者的左室舒张期充盈特征，使用脉冲多普勒超声心动图研究了 21 名 DC 和二尖瓣反流 (MR) 患者、12 名 DC 但无 MR 患者和 19 名年龄匹配的正常受试者的二尖瓣血流速度。 MR 的诊断基于左心房全收缩期湍流的多普勒超声心动图发现。通过多普勒二尖瓣流速记录测量舒张早期 (PFVE) 和心房收缩期间 (PFVA) 的峰值二尖瓣流速、PFVA/PFVE 和舒张早期流速的半减速时间。在 21 名 DC 和 MR 患者中，PFVE (61 ± 13 cm/s)、PFVA (37 ± 19 cm/s) 和 PFVA/PFVE (0.6 ± 0.4) 与正常受试者的 PFVE (53 ± 10 cm/s)、PFVA (47 ± 12 cm/s) 和 PFVA/PFVE (1.0 ± 0.4) 没有显着差异 (p > 0.05）。患有 MR 的 DC 患者的减速半衰期 (62 ± 32 ms) 比正常人 (87 ± 25 ms) 短 (p < 0.05)。相反，12 名无 MR 的 DC 患者的 PFVE (31 ± 11 cm/s) 较低，PFVA/PFVE (1.7 ± 0.8) 高于正常受试者和有 MR 的 DC 患者 (p < 0.005)。无 MR 患者的 PFVA (46 ± 8 cm/s) 和减速半时 (88 ± 33 ms) 与正常平均值没有显着差异。因此，在没有 MR 的 DC 患者中检测到峰值舒张期二尖瓣流速异常，但在有 MR 的 DC 患者中未检测到，这表明 MR 掩盖了 DC 患者的左心室充盈异常。
Patients with dilated cardiomyopathy (DC) have been reported to have abnormal left ventricular (LV) diastolic properties. To evaluate LV diastolic filling characteristics in patients with DC, pulsed Doppler echocardiography was used to study mitral flow velocity in 21 patients with DC and mitral regurgitation (MR), 12 patients with DC but no MR and 19 age-matched normal subjects. Diagnosis of MR was based on the Doppler echocardiographic finding of holosystolic turbulent flow in the left atrium. Peak mitral flow velocity in early diastole (PFVE) and during atrial systole (PFVA), PFVA/PFVE and deceleration half-time of early diastolic flow were measured from Doppler mitral flow velocity recordings. In 21 patients with DC and MR, PFVE (61 ± 13 cm/s), PFVA (37 ± 19 cm/s) and PFVA/PFVE (0.6 ± 0.4) were not significantly different from PFVE (53 ± 10 cm/s), PFVA (47 ± 12 cm/s) and PFVA/PFVE (1.0 ± 0.4) in normal subjects (p > 0.05). Deceleration half-time in DC patients with MR (62 ± 32 ms) was shorter than normal (87 ± 25 ms) (p < 0.05). In contrast, PFVE (31 ± 11 cm/s) was lower and PFVA/PFVE (1.7 ± 0.8) was higher in the 12 DC patients without MR than in normal subjects and DC patients with MR (p < 0.005). PFVA (46 ± 8 cm/s) and deceleration half-time (88 ± 33 ms) in patients without MR were not significantly different from normal mean values. Thus, abnormalities of peak diastolic mitral flow velocity were detected in DC patients without MR but not in DC patients with MR, suggesting that MR masks LV filling abnormalities in patients with DC.