Bouncing back: remission from depression in a 12-year panel study of a representative Canadian community sample
Bouncing back: remission from depression in a 12-year panel study of a representative Canadian community sample
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DOI：
10.1007/s00127-013-0814-8
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发表时间：
2014-06-01
影响因子：
4.4
通讯作者：
Brennenstuhl, Sarah
中科院分区：
文献类型：
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作者：
Fuller-Thomson, Esme;Battiston, Marla;Brennenstuhl, Sarah
本研究旨在调查一个以社区为基础的成年人样本的抑郁症缓解时间，随访12年。数据来自全国人口健康调查（1994/5-2006/7和1996/7-2008/9）。根据DSM-III/CIDI-SF标准，共有1，128名成年人在基线时患有抑郁症。Kaplan-Meier和考克斯比例风险程序用于确定缓解时间和人口统计学（例如，性别和婚姻状况），心理社会（例如，社会支持和不良童年经历）和健康相关（例如，疼痛、健康状况和酒精使用）与之相关的因素。超过四分之三的样本（77%）在2年时不再筛查抑郁症阳性，几乎整个样本（94%）在12年时已经缓解。童年的不良经历（即，儿童期虐待和父母增加）、缺乏社会支持、存在疼痛和健康状况（即，偏头痛、关节炎和背痛），每一种都预示着更长的缓解时间。在多变量分析中，与缓解时间相关的唯一因素是儿童期身体虐待史，大多数社区抑郁症患者在2年后好转，几乎所有人在12年前都至少缓解过一次。这项研究的结果可能有助于指导慢性抑郁症干预措施的发展，重点是早期预防儿童虐待。
This study sought to investigate time to remission from depression in a community-based sample of adults followed for 12 years.Data were derived from the National Population Health Survey (1994/5-2006/7 and 1996/7-2008/9). Fully 1,128 adults were included who were depressed at baseline according to DSM-III/CIDI-SF criteria. Kaplan-Meier and Cox proportional hazards procedures were used to determine time to remission and the demographic (e.g., gender and marital status), psychosocial (e.g., social support and adverse childhood experience) and health-related (e.g., pain, health conditions and alcohol use) factors with which it is associated.More than three quarters of the sample (77 %) no longer screened positive for depression at 2 years, and nearly the entire sample (94 %) had remitted by 12 years. Adverse childhood experiences (i.e., childhood abuse and parental additions), lack of social support, the presence of pain and health conditions (i.e., migraines, arthritis and back pain) each predicted more time to remission. The only factor associated with time to remission in the multivariate analysis was a history of childhood physical abuse.Most community members with depression get better after 2 years and nearly all will have remitted, at least once, by 12 years. The results of this study may help guide the development of interventions for chronic depression that focus on early prevention of childhood abuse.