INDIVIDUAL-DIFFERENCES IN SCHEDULE-INDUCED AND CONDITIONED BEHAVIORS
INDIVIDUAL-DIFFERENCES IN SCHEDULE-INDUCED AND CONDITIONED BEHAVIORS
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DOI：
10.1016/0166-4328(94)90148-1
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发表时间：
1994-02-28
影响因子：
2.7
通讯作者：
JUSTICE, JB
中科院分区：
文献类型：
--
作者：
HOOKS, MS;JONES, GH;JUSTICE, JB
先前的实验已经表明，表现出高运动反应的新奇性（HR）的主体也表现出更大的运动反应的精神兴奋剂比主体具有低运动反应的新环境（LR）。本实验旨在更详细地研究非药物范式中HR和LR大鼠之间的行为差异。在第一个实验中，HR大鼠比LR大鼠更容易获得时间表诱导的烦渴（SIP）。然而，与HR大鼠相比，LR大鼠获得食物颗粒的面板压力更大，特别是在达到稳定的SIP水平后。在第二个实验中，一组大鼠每天喂食后30分钟的时间在光电笼（食物调理; FC），而对照组饲养在家庭笼（非条件; NC）。与NC大鼠相比，FC受试者在试验笼中的最初30分钟内预期进食时出现了更高的运动活动。这种预期的运动活动发展更迅速，并在HR大鼠比LR大鼠更高的水平。多巴胺，二羟苯乙酸，高香草酸，5-羟色胺，5-羟基吲哚乙酸，和去甲肾上腺素的浓度进行了测定，在完成的行为测试中的食物条件和非条件的大鼠。食物条件实验表明，多巴胺能和多巴胺能系统的变化可能是行为反应性个体差异的基础。然而，没有出现明确的神经化学差异模式。目前的一组实验已经证明了HR和LR大鼠之间的差异，在非药物相关的范例，HR大鼠似乎表现出更大的动机兴奋诱导的定期食物交付比LR大鼠。
Previous experiments have shown that subjects which exhibit a high locomotor response to novelty (HR) also show a greater locomotor response to psychomotor stimulants than subjects which have a low locomotor response to a novel environment (LR). The current experiments were designed to examine in more detail the behavioral differences between HR and LR rats in non-drug paradigms. In the first experiment HR rats acquired schedule-induced polydipsia (SIP) more readily than LR rats. Panel pressing to gain access to the food pellets, however, was greater in LR rats compared to HR rats, especially after stable levels of SIP had been attained. In the second experiment one group of rats were fed daily after a 30-min period in photocell-cages (food conditioning; FC) while a control group was fed in the home-cage (non-conditioned; NC). FC subjects developed heightened locomotor activity in anticipation of feeding in the initial 30 min in the test-cage compared to NC rats. This anticipatory locomotor activity developed more rapidly and to a greater level in HR rats than in LR rats. The concentrations of dopamine, dihydroxyphenylacetic acid, homovanillic acid, serotonin, 5-hydroxyindoleactic acid, and norepinephrine were determined at the completion of behavioral testing in both the food conditioned and non-conditioned rats. The food conditioned experiment showed that variations in both the dopaminergic and serotoninergic systems may underlie individual differences in behavioral responsiveness. However, no clear pattern of neurochemical differences emerged. The current set of experiments have demonstrated differences between HR and LR rats in non-drug related paradigms and that HR rats appear to show a greater motivational excitement induced by periodic food delivery than LR rats.