Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents
Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents
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有证据表明，通过静脉注射吗啡，凝胶质的阿片受体有助于抑制无髓鞘初级传入神经冲动的脊髓传递
DOI：
10.1016/0006-8993(81)90698-3
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
A. Duggan
中科院分区：
文献类型：
--
作者：
S. Johnson;A. Duggan
在巴比妥麻醉猫，背角神经元兴奋的胫总神经的电刺激。镇痛剂量的吗啡（1-4 mg/kg）可抑制兴奋C纤维诱发的动作电位数目。在胶状质内注射纳洛酮可完全逆转吗啡的抑制作用。结果提示胶状质阿片受体在吗啡镇痛中起作用。
In barbiturate anaesthetized cats, dorsal horn neurones were excited by electrical stimulation of the common tibial nerve. The numbers of action potentials evoked by excitation of C fibres were depressed by analgesic doses of morphine (1–4 mg/kg i.v.). Naloxone, administered electrophoretically in the substantia gelatinosa, fully reversed the inhibitory action of morphine. The results suggest that opiate receptors in the substantia gelatinosa play a role in morphine analgesia.