LAMBDA-PLACMU INSERTIONS IN GENES OF THE LEUCINE REGULON - EXTENSION OF THE REGULON TO GENES NOT REGULATED BY LEUCINE
LAMBDA-PLACMU INSERTIONS IN GENES OF THE LEUCINE REGULON - EXTENSION OF THE REGULON TO GENES NOT REGULATED BY LEUCINE
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DOI：
10.1128/jb.174.6.1948-1955.1992
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发表时间：
1992-03-01
影响因子：
3.2
通讯作者：
NEWMAN, EB
中科院分区：
文献类型：
--
作者：
LIN, RT;DARI, R;NEWMAN, EB
The leucine regulon coordinates the expression of several Escherichia coli genes according to the presence of exogenous leucine, which interacts with the lrp gene product, Lrp. We isolated and characterized 22 strains with lambda-placMu insertions in Lrp-regulated genes. Lrp and leucine influenced gene expression in a surprising variety of ways. We identified two genes that are regulated by Lrp and not affected by L-leucine. We therefore rename this the leucine-lrp regulon. Genes coding for glycine cleavage and leucine biosynthesis enzymes have been identified as members of the leucine-lrp regulon. We suggest that the lrp gene product activates genes needed for growth in minimal medium, and we show that the gene is repressed by its own product and is highly repressed during growth in rich medium.
