Microglial Activation in Young Adults With Autism Spectrum Disorder
Microglial Activation in Young Adults With Autism Spectrum Disorder
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DOI：
10.1001/jamapsychiatry.2013.272
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发表时间：
2013-01-01
期刊：
影响因子：
25.8
通讯作者：
Mori, Norio
中科院分区：
文献类型：
--
作者：
Suzuki, Katsuaki;Sugihara, Genichi;Mori, Norio
内容：越来越多的证据表明，异常的免疫系统是自闭症谱系障碍（ASD）的病理生理特征的基础。然而，据我们所知，没有关于ASD患者大脑中小胶质细胞激活分布模式的信息。目的：识别整个大脑中与过度激活的小胶质细胞相关的大脑区域，并检查ASD患者和对照组患者中激活的小胶质细胞分布模式的相似性。设计：使用正电子发射断层扫描和放射性示踪剂对小胶质细胞[C-11]（R）进行的病例对照研究（1-[ 2-氯苯基]-N-甲基-N-[1-甲基丙基]-3-异喹啉甲酰胺）（[C-11]（R）-PK 11195）。设置：从社区招募的受试者。参与者：20名患有ASD的男性。（年龄范围，18-31岁;平均[SD] IQ，95.9 [16.7]）和20名年龄和IQ匹配的健康男性作为对照。ASD的诊断是按照自闭症诊断观察表和自闭症诊断访谈-修订版进行的。主要结果测量：局部脑[11 C]（R）PK 11195结合电位作为小胶质细胞活化的代表性测量。与对照组相比，年轻成人ASD患者多个脑区的[11 C]（R）-PK 11195结合电位值显著升高（P
Context: A growing body of evidence suggests that aberrant immunologic systems underlie the pathophysiologic characteristics of autism spectrum disorder (ASD). However, to our knowledge, no information is available on the patterns of distribution of microglial activation in the brain in ASD.Objectives: To identify brain regions associated with excessively activated microglia in the whole brain, and to examine similarities in the pattern of distribution of activated microglia in subjects with ASD and control subjects.Design: Case-control study using positron emission tomography and a radiotracer for microglia-[C-11](R)-(1[ 2-chrorophynyl]-N-methyl-N-[1-methylpropyl]-3 isoquinoline carboxamide) ([C-11](R)-PK11195).Setting: Subjects recruited from the community.Participants: Twenty men with ASD (age range, 18-31 years; mean [SD] IQ, 95.9 [16.7]) and 20 age-and IQ-matched healthy men as controls. Diagnosis of ASD was made in accordance with the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised.Main Outcome Measures: Regional brain [11C](R)PK11195 binding potential as a representative measure of microglial activation.Results: The [11C](R)-PK11195 binding potential values were significantly higher in multiple brain regions in young adults with ASD compared with those of controls (P