Zebrafish frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm
Zebrafish frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm
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DOI：
10.1016/s0925-4773(02)00221-6
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发表时间：
2002-10-01
影响因子：
2.6
通讯作者：
Calvey, CR
中科院分区：
文献类型：
--
作者：
Ungar, AR;Calvey, CR
Frizzled (fz) 基因编码 Wnt 信号通路的受体。我们描述了一种新的 fz 基因，斑马鱼 fz7b。 Matemalfz7b mRNA 可通过 RT-PCR 检测。胚胎fz7b广泛分布于早期胚轴阶段胚胎中。到盾阶段，胚盘边缘周围的表达似乎丰富。在脱落过程中，表达仅限于脊索前板、假定的中脑和后脑以及轴旁中胚层。当体节形成时，标记会短暂地以节段模式出现。到体细胞分裂中期，表达在前脑、前脑-中脑边界和前后脑中特别丰富，但在整个中枢神经系统头侧的大部分区域中表达水平较低。 CNS 表达位于腹侧和内侧位置。近轴中胚层表达仅限于尾芽。这种模式持续 26 小时。 48小时时，在咽弓和发育中的鳍中观察到弱表达。 (C) 2002 Elsevier Science Ireland Ltd. 保留所有权利。
Frizzled (fz) genes encode receptors for the Wnt signaling pathway. We describe a novel fz gene, zebrafish fz7b. Matemalfz7b mRNA is detectable by RT-PCR. Embryonic fz7b is widely distributed in early epiboly stage embryos. By shield stage, expression appears enriched around the blastoderm margin. During epiboly, expression becomes restricted to the prechordal plate, presumptive midbrain and hindbrain and paraxial mesoderm. As somites form, labeling is briefly present in a segmental pattern. By mid-somitogensis, expression is particularly enriched in the forebrain, the forebrain-midbrain boundary, and the anterior hindbrain, but appears at lower levels throughout much of the rostral CNS. The CNS expression is at ventral and medial positions. The paraxial mesoderm expression becomes restricted to the tailbud. This pattern continues through 26 h. At 48 h, weak expression is seen in the pharyngeal arches and developing fin. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.