Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia
Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia
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DOI：
10.1177/1358863x09104658
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发表时间：
2009-11-01
影响因子：
3.5
通讯作者：
Poldermans, Don
中科院分区：
文献类型：
--
作者：
Smolderen, Kim G.;Hoeks, Sanne E.;Poldermans, Don
外周动脉疾病（PAD）患者报告了多种临床表现，并不总是与经典的间歇性跛行一致。我们研究了非典型性劳力性腿部症状、间歇性跛行和开始于休息时的劳力性腿部症状与情绪状态如焦虑、抑郁症状和快感缺乏（即缺乏积极情感）的相关程度。来自荷兰鹿特丹伊拉斯谟医学中心的一组连续PAD患者（n = 628）完成了医院焦虑和抑郁量表和圣地亚哥跛行问卷。在基线时对所有患者的踝臂指数和临床因素进行评估。29%的患者存在焦虑，30%的患者存在抑郁症状，28%的患者存在快感缺乏。休息时疼痛与焦虑、抑郁症状和快感缺乏独立相关（OR在2.5和4.0之间，p
Patients with peripheral arterial disease (PAD) report diverse clinical manifestations that are not always consistent with classic intermittent claudication. We examined the degree to which atypical exertional leg symptoms, intermittent claudication, and exertional leg symptoms that begin at rest were associated with mood states such as anxiety, depressive symptoms, and anhedonia (i.e. lack of positive affect). A cohort of consecutive PAD patients (n = 628) from the Erasmus Medical Center, Rotterdam, The Netherlands, completed the Hospital Anxiety and Depression Scale and the San Diego Claudication questionnaire. The ankle-brachial index and clinical factors were assessed in all patients at baseline. Anxiety was present in 29%, depressive symptoms in 30%, and anhedonia in 28% of patients. Pain at rest was independently associated with anxiety, depressive symptoms, and anhedonia (ORs between 2.5 and 4.0, p