WNT5A and Its Receptors in the Bone‐Cancer Dialogue
WNT5A and Its Receptors in the Bone‐Cancer Dialogue
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DOI：
10.1002/jbmr.2899
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发表时间：
2016-08
影响因子：
6.2
通讯作者：
S. Thiele;T. Rachner;M. Rauner;L. Hofbauer
中科院分区：
文献类型：
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作者：
S. Thiele;T. Rachner;M. Rauner;L. Hofbauer
Wnt信号对肿瘤发生和骨骼重塑至关重要。然而，其对转移性骨病变形成的贡献仍不明确。揭示其在癌症进展中的作用的一个主要挑战是Wnt信号的高度复杂性，它包括许多配体、受体和抑制剂，具有复杂的生物效应和特定的信号通路，这取决于细胞环境。从这个角度来看，我们总结了非规范Wnt配体WNT5A在嗜骨性癌症实体的发展和转移过程中的作用。我们将重点关注其在乳腺癌中的肿瘤抑制功能，在黑色素瘤中的肿瘤促进作用，以及在前列腺癌中的模糊作用，并讨论靶向Wnt信号用于癌症治疗和骨转移治疗的潜在挑战和机遇。©2016美国骨与矿物研究学会。
Wnt signaling is critical for tumorigenesis and skeletal remodeling. However, its contribution to the formation of metastatic bone lesions remains poorly defined. One major challenge of unraveling its role in cancer progression is the high complexity of Wnt signaling, which includes numerous ligands, receptors, and inhibitors, with intricate biological effects and specific signaling pathways depending on the cellular context. In this perspective, we summarize the role of the noncanonical Wnt ligand WNT5A in the development and metastatic process of osteotropic cancer entities. We focus on its tumor‐suppressive function in breast cancer, tumor promoting effects in melanoma, and ambiguous role in prostate cancer, and discuss potential challenges and opportunities that may be associated with targeting Wnt signaling for cancer therapy and treatment of bone metastases. © 2016 American Society for Bone and Mineral Research.