The landscape of DNA methylation in hepatocellular carcinoma
The landscape of DNA methylation in hepatocellular carcinoma
复制标题
肝细胞癌中 DNA 甲基化的概况
DOI：
10.1002/jcp.27077
复制
发表时间：
2018-08
影响因子：
5.6
通讯作者：
Guan Bu Gao
中科院分区：
文献类型：
--
作者：
Zheng Yong Fa;Lu Xiaojie;Zhang Xiao Yu;Guan Bu Gao
更好地了解肝细胞癌整体甲基化状态的变化与疾病进展之间的关系，将有助于我们找到早期发现和治疗肝细胞癌患者的良好策略。本研究的目的是研究肝细胞癌患者甲基化状态变化与疾病进展的关系，以便对肝细胞癌患者进行早期发现和治疗。首先，提取了50例肝癌组织及其周围正常组织的DNA甲基化数据，研究了肝癌组织DNA启动子区甲基化状态与正常组织相比的变化规律。然后，使用k-top记分对方法确定了一些可以准确识别癌症和癌旁组织的DNA甲基化基因。此外，基于早期肝癌患者的总体生存时间和死亡信息，构建了一个可以预测肝癌患者生存的预后标志。最后，对得到的预测签名进行了验证。综上所述，本研究描述了肝癌发生发展过程中甲基化谱的变化，发现了与肝癌进展和预后相关的基因，这可能为肝癌的诊断和治疗提供新的机会。
Better understanding of the relationship between changes in the overall methylation status of hepatocellular carcinoma (HCC) and disease progression will help us find good strategies for the early detection and treatment of HCC patients. The purpose of the study was to study the relations between the methylation status changes in HCC patients and progression of the disease to enable early detection and treatment of HCC patients. First, the DNA methylation data of 50 HCC samples and the surrounding normal samples were extracted and the change pattern of methylation status in the DNA promoter region of HCC samples against that of normal samples was studied. Then, some DNA methylation genes that could accurately identify cancer and cancer‐adjacent tissues were identified using the k‐top scoring pair method. Also, a prognostic signature that could predict the survival of HCC patients was constructed based on the overall survival time and death information of the early HCC patients. Finally, the obtained prognostic signature was verified. In conclusion, this study described the changes in the methylation spectrum during the development of HCC and identified genes associated with HCC progression and prognosis, which may offer new opportunities for the diagnosis and treatment of HCC.
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影响因子：
3.5
作者：
He, Jingyang;Huang, Yuan;Qin, Yang
通讯作者：
Qin, Yang
DOI：
10.1038/nrgastro.2013.143
发表时间：
2014-01
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
通讯作者：
--
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
-D.;-R.;Cox
通讯作者：
-D.;-R.;Cox
影响因子：
5.1
作者：
Marrero, Jorge A;Pelletier, Shawn
通讯作者：
Pelletier, Shawn
影响因子：
5
作者：
Li, Qi;Li, Bai;Li, Qi
通讯作者：
Li, Qi