ASSOCIATION ANALYSIS FOR NEURONAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM WITH PLASMA NITRITE/NITRATE CONCENTRATION IN SCHIZOPHRENIA
ASSOCIATION ANALYSIS FOR NEURONAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM WITH PLASMA NITRITE/NITRATE CONCENTRATION IN SCHIZOPHRENIA
复制标题
DOI：
10.2478/jomb-2014-0023
复制
发表时间：
2014-10-01
影响因子：
2.5
通讯作者：
Doredevic, Vidosava
中科院分区：
文献类型：
--
作者：
Dordevic, Vladimir V.;Jevtovic-Stoimenov, Tatiana;Doredevic, Vidosava
背景：包括神经元型一氧化氮合酶(NOS1)基因在内的许多基因的单核苷酸多态(SNP)与精神分裂症密切相关。根据我们先前发表的精神分裂症患者血浆一氧化氮浓度升高的结果，我们假设NOS1基因多态性可能是精神分裂症患者一氧化氮产生增加的原因，并检验了血浆亚硝酸盐/硝酸盐浓度与人类NO1基因外显子29的SNP(CT突变)之间的相互关系。方法：采用比色法测定38例精神分裂症患者和39例年龄、性别匹配的健康人血浆中亚硝酸盐/硝酸盐浓度。结果：精神分裂症患者血浆亚硝酸盐/硝酸盐浓度显著高于对照组(97.5+/-33.3MU/L，P<0.05)。
Background: Single nucleotide polymorphisrns (SNP) of many genes, including the gene for neuronal nitric oxide synthase (NOS1), were found significantly associated with schizophrenia. According to our previously published results of increased plasma nitric oxide concentration in patients with schizophrenia, we hypothesized that the NOS1 gene polymorphism might be a cause of increased nitric oxide production in patients with schizophrenia and tested the interdependence between plasma nitrite/nitrate concentrations and SNP (a CT transition located in exon 29) of the human NOS1 gene.Methods: Nitrite/nitrate concentration was measured in blood plasma of 38 patients with schizophrenia and of 39 age and gender matched healthy persons by the colorimetric test. The NOS1 gene polymorphism was determined by polymerase chain reaction analysis.Results: A significantly higher plasma nitrite/nitrate concentration was found in patients with schizophrenia (97.5 +/- 33.3 mu mol/L, p