Survival Prognostic Value of Morphological and Metabolic variables in Patients with Stage I and II Non-Small Cell Lung Cancer
Survival Prognostic Value of Morphological and Metabolic variables in Patients with Stage I and II Non-Small Cell Lung Cancer
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DOI：
10.1007/s00330-015-3754-8
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发表时间：
2015-11-01
影响因子：
5.9
通讯作者：
Bernstine, H.
中科院分区：
文献类型：
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作者：
Domachevsky, L.;Groshar, D.;Bernstine, H.
非小细胞肺癌(NSCLC)患者的预后很重要，因为可切除疾病和预后变量较差的患者可能从新辅助治疗中受益。本研究的目的是评估SUVmax、SUVmax比率、CT体积(CTVOL)、代谢性肿瘤体积(MTV)和总病变糖酵解(TLG)作为生存预后指标。此外，我们定义了两个变量：MTV x SUVmax(MTVmax)和CTvolx SUVmax(CTvolmax)，并评估它们是否可以作为预后标志物。使用COX比例风险模型来确定变量与生存之间的关联。对无淋巴结(LN)受累的患者进行了类似的分析。纳入了181名患者(在研究结束时，140名患者还活着)。无论LN受累与否，SUVmax是显著的生存预后因素(P=0.012)。在无淋巴结转移的非小细胞肺癌患者中，SUVmax和CTVol(千分之7.1毫升)是有意义的预后因素，P=0.004和0.03。在I-II期非小细胞肺癌中，SUVmax是一个有用的预后变量，而在无淋巴结转移的病例中，形态肿瘤体积可能是有用的预后变量。
The prognosis of patients with non-small cell lung cancer (NSCLC) is important, as patients with resectable disease and poor prognostic variables might benefit from neoadjuvant therapy. The goal of this study is to evaluate SUVmax, SUVmax ratio, CT volume (CTvol), metabolic tumour volume (MTV) and total lesion glycolisis (TLG) as survival prognostic markers. In addition, we defined two variables; MTV x SUVmax (MTVmax) and CTvol x SUVmax (CTvolmax) and assessed whether they can be used as prognostic markers.Patients with stage I-II NSCLC who underwent 18 F FDG PET/CT and surgery were evaluated. Cox proportional-hazard model was used to determine the association between variables and survival. Similar analysis was performed in cases with no lymph node (LN) involvement.One hundred and eighty-one patients were included (at the end of the study, 140 patients were alive). SUVmax with a cut-off value of 8.2 was significant survival prognostic factor regardless of LN involvement (P = 0.012). In cases with no LN involvement, SUVmax and CTvol (a parts per thousand yen7.1 ml) were significant survival prognostic factors with P = 0.004 and 0.03, respectively.SUVmax may be a useful prognostic variable in stage I-II NSCLC while morphologic tumour volume might be useful in cases with no lymph node involvement.aEuro cent Identifying variables that predict the prognosis of patients with NSCLC is important.aEuro cent SUVmax in primary lung tumour is a useful independent prognostic variable.aEuro cent (CTvol) is an independent prognostic variable if no lymph nodes are involved.