Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity
Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity
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DOI：
10.1259/bjr/77297900
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发表时间：
2003-12-01
影响因子：
2.6
通讯作者：
Kim, CC
中科院分区：
文献类型：
--
作者：
Ahn, KJ;Lee, JW;Kim, CC
FK506是一种新开发的用于预防器官移植后排斥反应的高效免疫抑制剂。然而，FK506可引起中枢神经系统毒性。到目前为止，FK506神经毒性的发病机制尚不清楚。我们报告了一例FK506神经毒性患者的弥散加权MRI和表观弥散系数(ADC)图的结果，该患者在T-2加权图像、扩散加权图像和ADC图上显示双侧顶枕叶信号强度增加。这些发现表明，血管源性水肿而不是细胞毒性水肿可能在FK506神经毒性发病机制中起关键作用。
FK506 is a newly developed potent immunosuppressant for preventing rejection after organ transplantation. However, FK506 can induce central nervous system toxicity. Until now the pathogenic mechanism of FK506 neurotoxicity was unclear. We report the findings of diffusion-weighted MRI and apparent diffusion coefficient (ADC mapping of a FK506 neurotoxicity patient who showed increased signal intensities in both parieto-occipital lobes on T-2 weighted images, diffusion-weighted images and ADC maps. These findings suggest that a vasogenic oedema rather than a cytotoxic oedema may play a pivotal role in FK506 neurotoxicity pathogenesis.