LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus
LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus
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DOI：
10.1186/1756-6606-3-13
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发表时间：
2010-01-01
期刊：
影响因子：
3.6
通讯作者：
Inokuchi, Kaoru
中科院分区：
文献类型：
--
作者：
Kitamura, Takashi;Saitoh, Yoshito;Inokuchi, Kaoru
神经发生发生在各种动物的成年海马体中。新产生的神经元中有相当一部分在成熟前死亡，新神经元的存活率以经验依赖的方式进行调节。以往的研究表明，高频刺激海马齿状回（DG）的穿通通路纤维（perforant path fibers，HFS）可诱导DG的长时程增强（long-term potentiation，LTP），增强DG新生神经元的存活。在这项研究中，我们讨论了是否存在一个时间段，在此期间，新的神经元的生存是最敏感的HFS。我们发现，HFS对细胞存活的增强仅限于新生神经元未成熟阶段（出生后7-10天）的特定狭窄时期。此外，LTP诱导的药理学阻断抑制了HFS对细胞存活的增强。这些结果表明，LTP诱导在一个狭窄的关键时期的不成熟阶段，提高了大鼠DG中新产生的神经元的存活。
Neurogenesis occurs in the adult hippocampus of various animal species. A substantial fraction of newly generated neurons die before they mature, and the survival rate of new neurons are regulated in an experience-dependent manner. Previous study showed that high-frequency stimulation (HFS) of perforant path fibers to the hippocampal dentate gyrus (DG) induces the long-term potentiation (LTP) in the DG, and enhances the survival of newly generated neurons in the DG. In this study, we addressed whether a time period exists during which the survival of new neurons is maximally sensitive to the HFS. We found that the enhancement of cell survival by HFS was exclusively restricted to the specific narrow period during immature stages of new neurons (7-10 days after birth). Furthermore, the pharmacological blockade of LTP induction suppressed the enhancement of cell survival by the HFS. These results suggest that the LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in rat DG.